SynthesisCritical care (London, England)2008
A systematic review on quality indicators for tight glycaemic control in critically ill patients: need for an unambiguous indicator reference subset.
Synthesis in Critical care (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Glucose variability measures and their effect on mortality: a systematic review.Intensive care medicine · 2011Pooled it
- Tight glycemic control and computerized decision-support systems: a systematic review.Intensive care medicine · 2009Pooled it
- Ingredients for adequate evaluation of blood glucose algorithms as applied to the critically ill.Critical care (London, England) · 2009Pooled it
- Implementing glucose control in intensive care: a multicenter trial using statistical process control.Intensive care medicine · 2010Trial
- Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test case.Journal of the American Medical Informatics Association : JAMIATrial
- Risk and reward: extending stochastic glycaemic control intervals to reduce workload.Biomedical engineering online · 2020Article
- Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas.Critical care (London, England) · 2018Review
- Article
- Glucose Control in the ICU: A Continuing Story.Journal of diabetes science and technology · 2016Review
- Associations between blood glucose level and outcomes of adult in-hospital cardiac arrest: a retrospective cohort study.Cardiovascular diabetology · 2016Observational
- Study of a structured action pathway and persistent monitoring tool among nurses to achieve cent percent management of hypoglycaemia in in-patients: A measure of quality of healthcare.Medical journal, Armed Forces India · 2016Article
- Reporting on Glucose Control Metrics in the Intensive Care Unit.European endocrinology · 2015Review
- Designing effective visualizations of habits data to aid clinical decision making.BMC medical informatics and decision making · 2014Article
- Choosing the correct metrics for glucose control.Critical care (London, England) · 2014Article
- Association of serum glucose concentrations during acute hospitalization with hematoma expansion, perihematomal edema, and three month outcome among patients with intracerebral hemorrhage.Neurocritical care · 2011Article
- Carbohydrate provision in the era of tight glucose control.Current gastroenterology reports · 2011Review
- Phase II study of tight glycaemic control in COPD patients with exacerbations admitted to the acute medical unit.BMJ open · 2011Article
- Impact of a computer-generated alert system on the quality of tight glycemic control.Intensive care medicine · 2011Article
- Characteristics and effects of nurse dosing over-rides on computer-based intensive insulin therapy protocol performance.Journal of the American Medical Informatics Association : JAMIA · 2011Article
- International recommendations for glucose control in adult non diabetic critically ill patients.Critical care (London, England) · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe objectives of this study were to systematically identify and summarize quality indicators of tight glycaemic control in critically ill patients, and to inspect the applicability of their definitions.
methodsWe searched in MEDLINE for all studies evaluating a tight glycaemic control protocol and/or quality of glucose control that reported original data from a clinical trial or observational study on critically ill adult patients.
resultsForty-nine studies met the inclusion criteria; 30 different indicators were extracted and categorized into four nonorthogonal categories: blood glucose zones (for example, 'hypoglycaemia'); blood glucose levels (for example, 'mean blood glucose level'); time intervals (for example, 'time to occurrence of an event'); and protocol characteristics (for example, 'blood glucose sampling frequency'). Hypoglycaemia-related indicators were used in 43 out of 49 studies, acting as a proxy for safety, but they employed many different definitions. Blood glucose level summaries were used in 41 out of 49 studies, reported as means and/or medians during the study period or at a certain time point (for example, the morning blood glucose level or blood glucose level upon starting insulin therapy). Time spent in the predefined blood glucose level range, time needed to reach the defined blood glucose level target, hyperglycaemia-related indicators and protocol-related indicators were other frequently used indicators. Most indicators differ in their definitions even when they are meant to measure the same underlying concept. More importantly, many definitions are not precise, prohibiting their applicability and hence the reproducibility and comparability of research results.
conclusionsAn unambiguous indicator reference subset is necessary. The result of this systematic review can be used as a starting point from which to develop a standard list of well defined indicators that are associated with clinical outcomes or that concur with clinicians' subjective views on the quality of the regulatory process.
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