ArticleFibrogenesis & tissue repair2008
Experimental obstructive cholestasis: the wound-like inflammatory liver response.
Article in Fibrogenesis & tissue repair, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- A novel non-transecting ligation technique for clinically mimetic cholestatic cirrhosis in rats.Experimental animals · 2026Article
- Oxidative Stress and Antioxidant Defense During Liver Regeneration After Acetaminophen Toxicity: The Preventive Potential of the MicroalgaAntioxidants (Basel, Switzerland) · 2026Article
- The effect of Ankaferd blood stopper on liver damage in experimental obstructive jaundiceTurkish journal of medical sciences · 2021Article
- Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.Frontiers in pharmacology · 2021Review
- Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases.Redox biology · 2019Article
- Monitoring the Progression of Chronic Liver Damage in Rats Using [Molecular imaging and biology · 2019Article
- Acute-on-chronic liver disease enhances phenylephrine-induced endothelial nitric oxide release in rat mesenteric resistance arteries through enhanced PKA, PI3K/AKT and cGMP signalling pathways.Scientific reports · 2019Article
- N-acetyl-l-cysteine Prevents Bile Duct Ligation Induced Renal Injury by Modulating Oxidative Stress.Indian journal of clinical biochemistry : IJCB · 2017Article
- Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice.Scientific reports · 2017Article
- A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver.Scientific reports · 2017Article
- Nesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats.Bosnian journal of basic medical sciences · 2016Article
- Decompensated liver cirrhosis and neural regulation of mesenteric vascular tone in rats: role of sympathetic, nitrergic and sensory innervations.Scientific reports · 2016Article
- The Effect of Montelukast on Liver Damage in an Experimental Obstructive Jaundice Model.Viszeralmedizin · 2015Article
- Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis.Journal of visualized experiments : JoVE · 2015Article
- Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.BioMed research international · 2014Article
- A half century (1961-2011) of applying microsurgery to experimental liver research.World journal of hepatology · 2012Article
- The interstitial lymphatic peritoneal mesothelium axis in portal hypertensive ascites: when in danger, go back to the sea.International journal of inflammation · 2010Article
- Involvement of cholangiocyte proliferation in biliary fibrosis.World journal of gastrointestinal pathophysiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive cholestasis causes hepatic cirrhosis and portal hypertension. The pathophysiological mechanisms involved in the development of liver disease are multiple and linked. We propose grouping these mechanisms according to the three phenotypes mainly expressed in the interstitial space in order to integrate them.Experimental extrahepatic cholestasis is the model most frequently used to study obstructive cholestasis. The early liver interstitial alterations described in these experimental models would produce an ischemia/reperfusion phenotype with oxidative and nitrosative stress. Then, the hyperexpression of a leukocytic phenotype, in which Kupffer cells and neutrophils participate, would induce enzymatic stress. And finally, an angiogenic phenotype, responsible for peribiliary plexus development with sinusoidal arterialization, occurs. In addition, an intense cholangiocyte proliferation, which acquires neuroendocrine abilities, stands out. This histopathological finding is also associated with fibrosis.It is proposed that the sequence of these inflammatory phenotypes, perhaps with a trophic meaning, ultimately produces a benign tumoral biliary process - although it poses severe hepatocytic insufficiency. Moreover, the persistence of this benign tumor disease would induce a higher degree of dedifferentiation and autonomy and, therefore, its malign degeneration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.