ArticleThe Journal of infectious diseases2009
Pneumocystis colonization in immunocompetent and simian immunodeficiency virus-infected cynomolgus macaques.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Immunogenicity and protective efficacy of a pan-fungal vaccine in preclinical models of aspergillosis, candidiasis, and pneumocystosis.PNAS nexus · 2022Article
- Review
- A therapeutic vaccine strategy to preventFrontiers in immunology · 2022Article
- Vaccine-Induced Protection in Two Murine Models of Invasive Pulmonary Aspergillosis.Frontiers in immunology · 2021Article
- Pneumocystis jirovecii colonization and its association with pulmonary diseases: a multicenter study based on a modified loop-mediated isothermal amplification assay.BMC pulmonary medicine · 2020Article
- Immunization withHuman vaccines & immunotherapeutics · 2019Article
- Vaccine-Induced Immunogenicity and Protection Against Pneumocystis Pneumonia in a Nonhuman Primate Model of HIV and Pneumocystis Coinfection.The Journal of infectious diseases · 2016Article
- Investigation of Pneumocystis jirovecii colonization in patients with chronic pulmonary diseases in the People's Republic of China.International journal of chronic obstructive pulmonary disease · 2015Article
- Trimethoprim-sulfamethoxazole treatment does not reverse obstructive pulmonary changes in pneumocystis-colonized nonhuman primates with SHIV infection.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Antibody responses against Pneumocystis jirovecii in health care workers over time.Emerging infectious diseases · 2013Article
- Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension.American journal of respiratory cell and molecular biology · 2013Article
- Colonization by Pneumocystis jirovecii and its role in disease.Clinical microbiology reviews · 2012Review
- Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease.Immunologic research · 2011Article
- Serologic responses to pneumocystis proteins in HIV patients with and without Pneumocystis jirovecii pneumonia.Journal of acquired immune deficiency syndromes (1999) · 2011Article
- Alterations in peripheral blood B-cell populations in SHIV89.6P-infected macaques (Macacca fascicularis).Comparative medicine · 2011Article
- Decreased serum antibody responses to recombinant pneumocystis antigens in HIV-infected and uninfected current smokers.Clinical and vaccine immunology : CVI · 2011Article
- Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques.AIDS research and human retroviruses · 2011Article
- Clinical and translational research in pneumocystis and pneumocystis pneumonia.Parasite (Paris, France) · 2011Review
- Relationship of Pneumocystis jiroveci humoral immunity to prevention of colonization and chronic obstructive pulmonary disease in a primate model of HIV infection.Infection and immunity · 2010Article
- Persistent pneumocystis colonization leads to the development of chronic obstructive pulmonary disease in a nonhuman primate model of AIDS.The Journal of infectious diseases · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pneumocystis (Pc) colonization is common among human immunodeficiency virus (HIV)-infected subjects, although the clinical consequences of Pc carriage are not fully understood. We examined the frequency of asymptomatic carriage in healthy and simian immunodeficiency virus (SIV)-infected cynomolgus macaques by use of polymerase chain reaction (PCR) and assessment of changes in the serologic response to a recombinant fragment of the Pc protein kexin (KEX1). Anti-KEX1 antibodies were detected in 95% of healthy monkeys. To create a model of natural transmission of Pc, SIV-infected monkeys were cohoused with macaques coinfected with SIV and Pc. Pc colonization occurred when the CD4(+) T cell count decreased to <500 cells/microL, despite anti-Pc prophylaxis with trimethoprim-sulfamethoxazole. Increases in anti-KEX1 antibody titers preceded detection of Pc DNA in bronchoalveolar lavage (BAL) fluid samples by use of PCR. These results demonstrate the usefulness of recombinant KEX1 in serologic studies of Pc colonization and will improve the understanding of Pc transmission and clinical consequences of Pc colonization in HIV-infected patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.