ArticleBioorganic & medicinal chemistry letters2009
Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals.
Article in Bioorganic & medicinal chemistry letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males.Prostaglandins & other lipid mediators · 2018Trial
- Metabolic Mechanism ofInternational journal of environmental research and public health · 2023Article
- Synthesis, Quantification, and Characterization of Fatty Acid Amides from In Vitro and In Vivo Sources.Molecules (Basel, Switzerland) · 2021Review
- Article
- Review
- Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms.Frontiers in pharmacology · 2017Review
- Article
- Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells.Journal of lipid research · 2016Article
- Collaboration between primitive cell membranes and soluble catalysts.Nature communications · 2016Article
- Neuritogenic monoglyceride derived from the constituent of a marine fish for activating the PI3K/ERK/CREB signalling pathways in PC12 cells.International journal of molecular sciences · 2013Article
- Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor.Analytical biochemistry · 2013Article
- Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells.Journal of lipid research · 2012Article
- N-acylethanolamines as novel alcohol dehydrogenase 3 substrates.Archives of biochemistry and biophysics · 2011Article
- N-acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets.British journal of pharmacology · 2010Review
- Identification of endogenous acyl amino acids based on a targeted lipidomics approach.Journal of lipid research · 2010Article
- The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.BMC biochemistry · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
N-Arachidonoyl ethanolamide or anandamide is an endocannabinoid found in most tissues where it acts as an important signaling mediator in a number of physiological and pathophysiological processes. Consequently, intense effort has been focused on understanding all its biosynthetic and metabolic pathways. Herein we report human alcohol dehydrogenase-catalyzed sequential oxidation of anandamide to N-arachidonoyl glycine, a prototypical member of the class of long chain fatty acyl glycines, a new group of lipid mediators with a wide array of physiological effects. We also present a straightforward synthesis for a series of N-acyl glycinals including N-arachidonoyl glycinal, an intermediate in the alcohol dehydrogenase-catalyzed oxidation of anandamide.
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