ArticleBiological psychiatry2009
Preclinical atherosclerosis covaries with individual differences in reactivity and functional connectivity of the amygdala.
Article in Biological psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Trial
- Structural Carotid Atherosclerosis and Mild Behavioral Impairment: A Cross-Sectional Study in a Community-Dwelling Population.The Kaohsiung journal of medical sciences · 2026Article
- Amygdala volume is not associated with MRI-based markers of early cardiovascular disease.Insights into imaging · 2026Article
- A novel approach to the prevention and management of cardiovascular diseases: targeting brain-heart axis.European journal of medical research · 2025Review
- Age modulates the link between stress-related neural activity and mortality.Nature communications · 2025Article
- Stressor-Evoked Brain Activity, Cardiovascular Reactivity, and Subclinical Atherosclerosis in Midlife Adults.Journal of the American Heart Association · 2025Article
- Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review).Biomedical reports · 2025Review
- Imaging of the brain-heart axis: prognostic value in a European setting.European heart journal · 2024Article
- The Impact of Stress and Social Determinants on Diet in Cardiovascular Prevention in Young Women.Nutrients · 2024Review
- Stressor-evoked brain activity, cardiovascular reactivity, and subclinical atherosclerosis in midlife adults.medRxiv : the preprint server for health sciences · 2024Article
- Central stress pathways in the development of cardiovascular disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Psychological risk factors and cardiovascular disease.Frontiers in psychology · 2024Review
- The Impact of Mental Stress on Cardiovascular Health-Part II.Journal of clinical medicine · 2022Review
- Mental Stress and Its Effects on Vascular Health.Mayo Clinic proceedings · 2022Review
- The Association Between the Duration, Treatment, Control of Hypertension and Lifestyle Risk Factors in Middle-Aged and Elderly Patients with Mild Cognitive Impairment: A Case-Control Study.Neuropsychiatric disease and treatment · 2022Article
- Autonomic Neural Circuit and Intervention for Comorbidity Anxiety and Cardiovascular Disease.Frontiers in physiology · 2022Review
- Susceptibility of Women to Cardiovascular Disease and the Prevention Potential of Mind-Body Intervention by Changes in Neural Circuits and Cardiovascular Physiology.Biomolecules · 2021Review
- Affective brain patterns as multivariate neural correlates of cardiovascular disease risk.Social cognitive and affective neuroscience · 2020Article
- Disentangling the Links Between Psychosocial Stress and Cardiovascular Disease.Circulation. Cardiovascular imaging · 2020Review
- Associations of depression-anxiety and dyslipidaemia with subclinical carotid arterial disease: Findings from the Whitehall II Study.European journal of preventive cardiology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundCardiovascular disease (CVD) is a major source of medical comorbidity for patients with mood and anxiety disorders, and it remains the leading public health burden for the general population in industrialized nations. Indirect neurobiological evidence suggests that preclinical risk for atherosclerosis, the main contributor to CVD, may be conferred by interindividual variation in the functionality of the amygdala, a brain system jointly involved in processing behaviorally salient stimuli and regulating the cardiovascular system.
methodsIn a neuroimaging study of 36 middle-aged adults (18 women) who were screened for confounding clinical cardiovascular and psychiatric disorders, we examined the direct covariation between a marker of preclinical atherosclerosis, carotid artery intima-media thickness (IMT), and interindividual variation in amygdala reactivity and functional connectivity assessed during the processing of behaviorally salient stimuli (angry and fearful facial expressions).
resultsAfter accounting for traditional CVD risk factors, a thickening of carotid IMT across individuals covaried with greater amygdala reactivity and a more positive functional connectivity between the amygdala and perigenual anterior cingulate cortex, a corticolimbic area also implicated in behavioral salience processing and cardiovascular regulation.
conclusionsIndividual differences in amygdala reactivity and functional connectivity may reflect facets of a novel, systems-level neural phenotype conferring risk for atherosclerosis and CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.