ArticleArchives of oral biology2009
A comparison of primary and passaged chondrocytes for use in engineering the temporomandibular joint.
Article in Archives of oral biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Carrageenan-Based Crowding and Confinement Combination Approach to Increase Collagen Deposition for In Vitro Tissue Development.Gels (Basel, Switzerland) · 2023Article
- Advances in 3D printing techniques for cartilage regeneration of temporomandibular joint disc and mandibular condyle.International journal of bioprinting · 2023Review
- Advances in Tissue Engineering of the Temporomandibular Joint Disc: An Overview of Current Status and Future Directions.International journal of dentistry · 2022Review
- Advancements in temporomandibular joint total joint replacements (TMJR).Biomedical engineering letters · 2019Review
- Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.Stem cells (Dayton, Ohio) · 2019Article
- Tissue Engineering for the Temporomandibular Joint.Advanced healthcare materials · 2019Review
- Considerations for translation of tissue engineered fibrocartilage from bench to bedside.Journal of biomechanical engineering · 2018Article
- Matrix-associated chondrocyte transplantation for reconstruction of articulating surfaces in the temporomandibular joint: a pilot study covering medium- and long-term outcomes of 6 patients.Oral surgery, oral medicine, oral pathology and oral radiology · 2018Article
- Temporomandibular Joint Regenerative Medicine.International journal of molecular sciences · 2018Review
- A review of in-vitro fibrocartilage tissue engineered therapies with a focus on the temporomandibular joint.Archives of oral biology · 2017Review
- The Yucatan Minipig Temporomandibular Joint Disc Structure-Function Relationships Support Its Suitability for Human Comparative Studies.Tissue engineering. Part C, Methods · 2017Article
- Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders.Current osteoporosis reports · 2016Review
- Fibrochondrocyte Growth and Functionality on TiO₂ Nanothin Films.Journal of functional biomaterials · 2016Article
- Stem Cells for Temporomandibular Joint Repair and Regeneration.Stem cell reviews and reports · 2015Review
- The pilot study of fibrin with temporomandibular joint derived synovial stem cells in repairing TMJ disc perforation.BioMed research international · 2014Article
- Poly (glycerol sebacate): a novel scaffold material for temporomandibular joint disc engineering.Tissue engineering. Part A · 2013Article
- Toward engineering a biological joint replacement.The journal of knee surgery · 2012Review
- Article
- A comparison of the mechanical properties of the goat temporomandibular joint disc to the mandibular condylar cartilage in unconfined compression.Journal of dental biomechanics · 2011Article
- Temporomandibular disorders: a review of etiology, clinical management, and tissue engineering strategies.The International journal of oral & maxillofacial implantsReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis study examines the tissue engineering potential of passaged (P3) and primary (P0) articular chondrocytes (ACs) and costal chondrocytes (CCs) from skeletally mature goats for use in the temporomandibular joint (TMJ).
designThese four cell types were assembled into scaffoldless tissue engineered constructs and cultured for 4 wks. The constructs were then tested for cell, collagen, and glycosaminoglycan (GAG) content with biochemical assays, and collagen types I and II with enzyme-linked immunosorbent assays. Constructs were also tested under tension and compression to determine biomechanical properties.
resultsBoth primary and passaged CC constructs had greater GAG/wet weight than AC constructs. Primary AC constructs had significantly less total collagen and contained no collagen type I. AC P3 constructs had the largest collagen I/collagen II ratio, which was also greater in passaged CC constructs relative to primary groups. Primary AC constructs were not mechanically testable, whereas passaged AC and CC constructs had significantly greater tensile properties than primary CC constructs.
conclusionsPrimary CCs are considerably better than primary ACs and have potential use in tissue engineering when larger quantities of collagen type II are desired. The poor performance of the ACs, in this study, which contradicts the results seen with previous studies using immature bovine ACs, may thus be attributed to the animals' maturity. However, CC P3 cells appear particularly well suited for tissue engineering fibrocartilage of the TMJ due to the high quantity of collagen and GAG, and tensile and compressive mechanical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.