ArticleNeurobiology of disease2009
Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo.
Article in Neurobiology of disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Organization of sympathetic innervation of interscapular brown adipose tissue in the mouse.The Journal of comparative neurology · 2022Article
- Decoding the rosetta stone of mitonuclear communication.Pharmacological research · 2020Review
- Mitochondrial retrograde signalling in neurological disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness.PLoS genetics · 2018Review
- Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson's disease model.Scientific reports · 2018Article
- The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilising activity.Histochemistry and cell biology · 2017Article
- Neuronal hemoglobin affects dopaminergic cells' response to stress.Cell death & disease · 2017Article
- Review
- Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains.Oncotarget · 2016Article
- Targeting histone deacetylases: a novel approach in Parkinson's disease.Parkinson's disease · 2015Review
- Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.Neurobiology of disease · 2014Article
- PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice.Neuroscience · 2013Article
- Current status and future directions of gene expression profiling in Parkinson's disease.Neurobiology of disease · 2012Review
- Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat.Journal of neurotrauma · 2011Article
- Integrating multiple aspects of mitochondrial dynamics in neurons: age-related differences and dynamic changes in a chronic rotenone model.Neurobiology of disease · 2011Article
- Neuron-selective changes in RNA transcripts related to energy metabolism in toxic models of parkinsonism in rodents.Neurobiology of disease · 2010Article
- Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.Neurotoxicity research · 2010Article
- Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease.Molecular neurodegeneration · 2009Article
- Neurons express hemoglobin alpha- and beta-chains in rat and human brains.The Journal of comparative neurology · 2009Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Mitochondrial complex I inhibition has been implicated in the degeneration of midbrain dopaminergic (DA) neurons in Parkinson's disease. However, the mechanisms and pathways that determine the cellular fate of DA neurons downstream of the mitochondrial dysfunction have not been fully identified. We conducted cell-type specific gene array experiments with nigral DA neurons from rats treated with the complex I inhibitor, rotenone, at a dose that does not induce cell death. The genome wide screen identified transcriptional changes in multiple cell death related pathways that are indicative of a simultaneous activation of both degenerative and protective mechanisms. Quantitative PCR analyses of a subset of these genes in different neuronal populations of the basal ganglia revealed that some of the changes are specific for DA neurons, suggesting that these neurons are highly sensitive to rotenone. Our data provide insight into potentially defensive strategies of DA neurons against disease relevant insults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.