ArticleCell2008
The safety on the TCR trigger.
Article in Cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Membrane-Based Assembly and Interactions in Immune Receptors.Chemical reviews · 2026Review
- The TCR and LCK: foundations for T-cell activation and therapeutic innovation.Frontiers in immunology · 2025Review
- Article
- KIR signaling is regulated by electrostatic interaction of its cytosolic tail with the plasma membrane despite being neutral polyampholyte.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- T cell receptor (TCR) signaling in health and disease.Signal transduction and targeted therapy · 2021Review
- Plasma Membrane Integrates Biophysical and Biochemical Regulation to Trigger Immune Receptor Functions.Frontiers in immunology · 2021Review
- T Cell Activation Machinery: Form and Function in Natural and Engineered Immune Receptors.International journal of molecular sciences · 2020Review
- The cytosolic domain of T-cell receptor ζ associates with membranes in a dynamic equilibrium and deeply penetrates the bilayer.The Journal of biological chemistry · 2017Article
- Introducing Membrane Charge and Membrane Potential to T Cell Signaling.Frontiers in immunology · 2017Review
- Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Conformational states of the kinase Lck regulate clustering in early T cell signaling.Nature immunology · 2013Article
- Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement.Frontiers in immunology · 2012Article
- Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?Frontiers in immunology · 2012Article
- The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events.Frontiers in immunology · 2012Article
- TCR Signaling Emerges from the Sum of Many Parts.Frontiers in immunology · 2012Article
- The integration of signaling and the spatial organization of the T cell synapse.Frontiers in immunology · 2012Article
- Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.