ArticleAmerican journal of human genetics2008
Divergence between human populations estimated from linkage disequilibrium.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genetic diversity, population structure, and combined detection of selection signatures in Iranian versus Afghan Baluchi sheep.PloS one · 2026Article
- Genome-wide diversity, population structure and signatures of inbreeding in the African buffalo in Mozambique.BMC ecology and evolution · 2024Article
- Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores.Nature genetics · 2022Article
- The Origin of Additive Genetic Variance Driven by Positive Selection.Molecular biology and evolution · 2020Article
- Estimating linkage disequilibrium from genotypes under Hardy-Weinberg equilibrium.BMC genetics · 2020Article
- Exact Distribution of Linkage Disequilibrium in the Presence of Mutation, Selection, or Minor Allele Frequency Filtering.Frontiers in genetics · 2020Article
- Adaptation in structured populations and fuzzy boundaries between hard and soft sweeps.PLoS computational biology · 2019Article
- Estimating cross-population genetic correlations of causal effect sizes.Genetic epidemiology · 2019Article
- One Hundred Years of Linkage Disequilibrium.Genetics · 2018Article
- Maximizing crossbred performance through purebred genomic selection.Genetics, selection, evolution : GSE · 2015Article
- Revisiting demographic processes in cattle with genome-wide population genetic analysis.Frontiers in genetics · 2015Article
- SNeP: a tool to estimate trends in recent effective population size trajectories using genome-wide SNP data.Frontiers in genetics · 2015Article
- Extent of Linkage Disequilibrium and Effective Population Size in Four South African Sanga Cattle Breeds.Frontiers in genetics · 2015Article
- Additive genetic variation in schizophrenia risk is shared by populations of African and European descent.American journal of human genetics · 2013Article
- Article
- Estimation of linkage disequilibrium in four US pig breeds.BMC genomics · 2012Article
- Article
- A map of human microRNA variation uncovers unexpectedly high levels of variability.Genome medicine · 2012Article
- Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs.Genome research · 2011Article
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3 authors.
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Abstract
Observed linkage disequilibrium (LD) between genetic markers in different populations descended independently from a common ancestral population can be used to estimate their absolute time of divergence, because the correlation of LD between populations will be reduced each generation by an amount that, approximately, depends only on the recombination rate between markers. Although drift leads to divergence in allele frequencies, it has less effect on divergence in LD values. We derived the relationship between LD and time of divergence and verified it with coalescent simulations. We then used HapMap Phase II data to estimate time of divergence between human populations. Summed over large numbers of pairs of loci, we find a positive correlation of LD between African and non-African populations at levels of up to approximately 0.3 cM. We estimate that the observed correlation of LD is consistent with an effective separation time of approximately 1,000 generations or approximately 25,000 years before present. The most likely explanation for such relatively low separation times is the existence of substantial levels of migration between populations after the initial separation. Theory and results from coalescent simulations confirm that low levels of migration can lead to a downward bias in the estimate of separation time.
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