ArticleThe Lancet. Oncology2008
Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletion.
Article in The Lancet. Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Irradiation with a mixed heavy ion beam induces ovarian follicle loss and dose-dependent mixed ovarian tumor development.Biology of reproduction · 2026Article
- Oxidative Stress, Parity History, and Remnant Follicles in the Aged Ovary: Insights on Ovarian Cancer Risk and Protection.Antioxidants (Basel, Switzerland) · 2025Review
- Development of CSOARG: a single-cell and multi-omics-based machine learning model for ovarian cancer prognosis and drug response prediction.Frontiers in oncology · 2025Article
- Transcriptomic Analysis of the Aged Nulliparous Mouse Ovary Suggests a Stress State That Promotes Pro-Inflammatory Lipid Signaling and Epithelial Cell Enrichment.International journal of molecular sciences · 2023Article
- Sex differences in socioemotional behavior and changes in ventral hippocampal transcription across aging in C57Bl/6J mice.Neurobiology of aging · 2023Article
- The prognostic significance of human ovarian aging-related signature in breast cancer after surgery: A multicohort study.Frontiers in immunology · 2023Article
- Decreased risk of ovarian cancer associated with rs9898876 sex hormone-binding globulin gene variant.Molecular biology reports · 2022Article
- Aged mice ovaries harbor stem cells and germ cell nests but fail to form follicles.Journal of ovarian research · 2022Article
- Mechanisms of High-Grade Serous Carcinogenesis in the Fallopian Tube and Ovary: Current Hypotheses, Etiologic Factors, and Molecular Alterations.International journal of molecular sciences · 2021Review
- Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system.The EMBO journal · 2021Article
- Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection.Biomolecules · 2020Article
- Anti-Mullerian hormone levels in female cancer patients of reproductive age in Indonesia: A cross-sectional study.F1000Research · 2019Article
- Nitrogen mustard exposure perturbs oocyte mitochondrial physiology and alters reproductive outcomes.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.Molecular and cellular endocrinology · 2017Article
- Article
- Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases.Cell death & disease · 2016Article
- Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis.Molecular and cellular biology · 2016Article
- Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium.Oncotarget · 2016Article
- Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice.Neoplasia (New York, N.Y.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The association between ovarian cancer risk and reproductive factors has been well established, and two main theories, incessant ovulation and gonadotropin stimulation, have been proposed to explain the mechanism. Recent studies using animal models of ovarian tumorigenesis, and analysis of ovarian tissues from prophylactic oophorectomies, suggest that depletion of ovarian follicles might underlie the epidemiological findings linking reproductive history and ovarian cancer risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.