ArticleAnalytica chimica acta2008
Simultaneous generation of multiple aqueous droplets in a microfluidic device.
Article in Analytica chimica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Programmable µChopper Device with On-Chip Droplet Mergers for Continuous Assay Calibration.Micromachines · 2020Article
- Single-Molecule Flow Platform for the Quantification of Biomolecules Attached to Single Nanoparticles.Analytical chemistry · 2018Article
- Massively parallel and multiparameter titration of biochemical assays with droplet microfluidics.Nature protocols · 2017Article
- The potential impact of droplet microfluidics in biology.Analytical chemistry · 2013Article
- Droplet microfluidics driven by gradients of confinement.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- High-resolution dose-response screening using droplet-based microfluidics.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Creation of stepwise concentration gradient in picoliter droplets for parallel reactions of matrix metalloproteinase II and IX.Analytical chemistry · 2011Article
- Ultrasensitive and high-throughput fluorescence analysis of droplet contents with orthogonal line confocal excitation.Analytical chemistry · 2010Article
- Droplet freezing, docking, and the exchange of immiscible phase and surfactant around frozen droplets.Lab on a chip · 2010Article
- Droplets for ultrasmall-volume analysis.Analytical chemistry · 2009Article
- Chemistry and biology in femtoliter and picoliter volume droplets.Accounts of chemical research · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This paper describes a microfluidic platform for the on-demand generation of multiple aqueous droplets, with varying chemical contents or chemical concentrations, for use in droplet based experiments. This generation technique was developed as a complement to existing techniques of continuous-flow (streaming) and discrete-droplet generation by enabling the formation of multiple discrete droplets simultaneously. Here sets of droplets with varying chemical contents can be generated without running the risk of cross-contamination due to the isolated nature of each supply inlet. The use of pressure pulses to generate droplets in parallel is described, and the effect of droplet size is examined in the context of flow rates and surfactant concentrations. To illustrate this technique, an array of different dye-containing droplets was generated, as well as a set of droplets that displayed a concentration gradient of a fluorescent dye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.