ArticleThe international journal of neuropsychopharmacology2009
Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action.
Article in The international journal of neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Specialized Information Processing Deficits and Distinct Metabolomic Profiles Following TM-Domain Disruption of Nrg1.Schizophrenia bulletin · 2017Article
- Aberrant Salience Is Related to Reduced Reinforcement Learning Signals and Elevated Dopamine Synthesis Capacity in Healthy Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sex differences in animal models of psychiatric disorders.British journal of pharmacology · 2014Review
- Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2)-deficient mice: do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?Journal of psychopharmacology (Oxford, England) · 2014Article
- From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations.Frontiers in systems neuroscience · 2014Review
- Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.Frontiers in behavioral neuroscience · 2014Review
- D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Dopamine D1 receptor involvement in latent inhibition and overshadowing.The international journal of neuropsychopharmacology · 2012Article
- Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
Latent inhibition (LI) is reduced learning to a stimulus that has previously been experienced without consequence. It is an important model of abnormal allocation of salience to irrelevant information in patients with schizophrenia. In rodents LI is abolished by psychotomimetic drugs and in experimental conditions where LI is low in controls, its expression is enhanced by antipsychotic drugs with activity at dopamine (DA) receptors. It is however unclear what the independent contributions of DA receptor subtypes are to these effects. This study therefore examined LI in congenic DA D1 and D2 receptor knockout (D1 KO and D2 KO) mice. Conditioned suppression of drinking was used as the measure of learning in the LI procedure. Both male and female DA D2 KO mice showed clear enhancement of LI reproducing antipsychotic drug effects in the model. Unexpectedly, enhancement was also seen in D1 KO female mice but not in D1 KO male mice. This sex-specific pattern was not replicated in locomotor or motor coordination tasks nor in the effect of DA KOs on baseline learning in control groups indicating some specificity of the effect to LI. These data suggest that the dopaminergic mechanism underlying LI potentiation and possibly antipsychotic action may differ between the sexes, being mediated by D2 receptors in males but by both D1 and D2 receptors in females. These data suggest that the DA D1 receptor may prove an important target for understanding sex differences in the mechanisms of action of antipsychotic drugs and in the aetiology of aberrant salience allocation in schizophrenia.
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Registered trials
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