ArticleBiochemistry2008
The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition.
Article in Biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner.Biomolecules · 2021Article
- Article
- A novel mode of interaction between intrinsically disordered proteins.Biophysics and physicobiology · 2020Review
- Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability.Protein science : a publication of the Protein Society · 2018Review
- Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness.Cellular and molecular life sciences : CMLS · 2017Review
- Review
- Interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4.Protein science : a publication of the Protein Society · 2016Article
- Dynamic association of PfEMP1 and KAHRP in knobs mediates cytoadherence during Plasmodium invasion.Scientific reports · 2015Article
- Advantages of proteins being disordered.Protein science : a publication of the Protein Society · 2014Review
- Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain.Biochemistry · 2014Article
- A decade and a half of protein intrinsic disorder: biology still waits for physics.Protein science : a publication of the Protein Society · 2013Review
- Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.PLoS pathogens · 2013Article
- Evolution of immunity: no development without risk.Immunologic research · 2012Review
- The impact of small molecule binding on the energy landscape of the intrinsically disordered protein C-myc.PloS one · 2012Article
- Expanding the proteome: disordered and alternatively folded proteins.Quarterly reviews of biophysics · 2011Article
- Cells diversify transmembrane signaling through the controlled chaos of protein disorder.Self/nonself · 2011Article
- Differential occurrence of protein intrinsic disorder in the cytoplasmic signaling domains of cell receptors.Self/nonself · 2011Article
- The SCHOOL of nature: IV. Learning from viruses.Self/nonself · 2010Article
- Unusual biophysics of immune signaling-related intrinsically disordered proteins.Self/nonself · 2010Article
- Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators.Structure (London, England : 1993) · 2010Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Intrinsically disordered proteins are thought to undergo coupled binding and folding upon interaction with their folded partners. In this study, we investigate whether binding of the intrinsically disordered T cell receptor zeta cytoplasmic tail to the well-folded simian immunodeficiency virus Nef core domain is accompanied by a disorder-to-order transition. We show that zeta forms a 1:1 complex with Nef and remains unfolded in the complex. Thus, our findings oppose the generally accepted view of the behavior of intrinsically disordered proteins and provide new evidence of the existence of specific interactions for unfolded protein molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.