Evidence map›Paper›PMID 19012341›Full record

ArticleAmerican journal of medical genetics. Part A2008

Familial twinning and fertility in Dutch mothers of twins.

Chantal Hoekstra, Gonneke Willemsen, Toos C E M van Beijsterveldt, Grant W Montgomery, Dorret I Boomsma

Open access · greenAbstract readTwin Study
In one paragraph

Article in American journal of medical genetics. Part A, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. New insights into the (epi)genetics of twinning.Human reproduction (Oxford, England) · 2024
    Pooled it
  2. Evolution of Litter Size: Proximate and Ultimate Mechanisms.Integrative and comparative biology · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Association Between rs1051730 and Smoking During Pregnancy in Dutch Women.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Article
  7. Article
  8. Article
  9. Frequency of Prader-Willi syndrome in births conceived via assisted reproductive technology.Genetics in medicine : official journal of the American College of Medical Genetics · 2014
    Article
  10. The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013
    Article
  11. Why is lifetime fertility higher in twinning women?Proceedings. Biological sciences · 2012
    Article
  12. Article
  13. Article
  14. Article
  15. Fetal constraint as a potential risk factor for craniosynostosis.American journal of medical genetics. Part A · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chantal HoekstraDepartment of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Gonneke Willemsen
Toos C E M van Beijsterveldt
Grant W Montgomery
Dorret I Boomsma
Vrije Universiteit Amsterdam · NLQIMR Berghofer Medical Research Institute · AU

Funding

Collaborative Study of Genetics of Dizygotic TwinningR01HD042157 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MONTGOMERY, GRANT W · 2002 to 2006
$2.0M
NICHD NIH HHS HD042157NICHD NIH HHS R01 HD042157
6 · The paper itself

Abstract

We studied twinning and fertility indices in mothers with spontaneous monozygotic (MZ) and dizygotic (DZ) twins and in mothers who conceived their twins after the use of assisted reproduction techniques (ART). Participants in this study consisted of 8,222 and 5,505 women with spontaneous DZ and MZ offspring and 4,164 and 250 women with ART DZ and MZ twin pairs, respectively. Women were compared with respect to the number of sibs and offspring, the presence of other relatives with twins and the time it took to conceive the twins. We also compared familial twinning between a younger and an older age group. Women with spontaneous DZ twins more often reported female relatives with twins than those with spontaneous MZ twins. The proportion of DZ versus MZ twin offspring in relatives was also larger in women with spontaneous DZ offspring than in women with MZ offspring. The first group of women reported a shorter time to conceive. Women with ART twins had fewer sibs and offspring and less often reported relatives with twins. We did not observe that DZ twinning was more familial in women who had their twins before age 36 years compared to older women. Familial DZ twinning is clearly present in mothers of spontaneous DZ twins. The mechanisms underlying spontaneous and non-spontaneous DZ twinning are different and fertility treatment should be taken into account in any study of twinning. Twinning is not more familial in women who have their twins at a younger age.

Indexed as

FamilyFertilityMothersTwins, DizygoticTwins, MonozygoticFemaleHumansMaleNetherlandsReproductive Techniques, AssistedSiblingsTime Factors

Identifiers

PMID19012341
PMCPMC2852646
OpenAlexW2017392762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.