ArticleClinical and experimental nephrology2008
Proposal of podocytic infolding glomerulopathy as a new disease entity: a review of 25 cases from nationwide research in Japan.
Article in Clinical and experimental nephrology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Podocytic infolding glomerulopathy: two new cases with connective tissue disease and literature review.Clinical rheumatology · 2019Pooled it
- Morphological subtypes and clinicopathological features of podocyte infolding glomerulopathy: retrospective nationwide Japanese cohort study of 93 cases.Clinical and experimental nephrology · 2026Article
- Podocytic Infolding Gromerulopathy Developed at the Time of Transition from Chronic Myelogenous Leukemia to Myelodysplastic Syndrome.Internal medicine (Tokyo, Japan) · 2026Article
- Histopathological Examination of Clustering Microspheres and Podocyte Infolding in the Glomerular Basement Membrane Using Low-vacuum Scanning Electron Microscopy.Internal medicine (Tokyo, Japan) · 2026Article
- Podocyte infolding glomerulopathy in a Japanese girl with systemic lupus erythematosus.CEN case reports · 2026Article
- Podocyte Infolding Glomerulopathy: A Special Morphology of Podocyte Injury Caused by Heterogeneous Diseases.Kidney international reports · 2023Article
- Diagnosis of Glomerular Disease With Podocyte Infolding, Microspherical, and Microtubular Glomerular Basement Membrane Inclusions.Kidney international reports · 2023Article
- IgA nephropathy with podocytic infolding glomerulopathy.Chronic diseases and translational medicine · 2023Article
- Integrated Chinese and Western medicine in the treatment of a patient with podocyte infolding glomerulopathy: A case report.World journal of clinical cases · 2023Article
- Podocyte Infolding Glomerulopathy: A Case Series Report and Literature Review.Journal of clinical medicine · 2023Article
- Podocyte infolding glomerulopathy after 25 years of clinical remission of lupus nephritis in a patient with systemic lupus erythematosus: A case report and review of literature.Clinical case reports · 2022Article
- A case of Podocytic Infolding Glomerulopathy with SLE and literature review.BMC nephrology · 2021Review
- Podocyte Infolding Glomerulopathy, First Case Report From North America.Canadian journal of kidney health and disease · 2021Article
- Podocytic infolding in Schimke immuno-osseous dysplasia with novel SMARCAL1 mutations: a case report.BMC nephrology · 2020Article
- Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome.BMC nephrology · 2019Article
- Podocyte penetration of the glomerular basement membrane to contact on the mesangial cell at the lesion of mesangial interposition in lupus nephritis: a three-dimensional analysis by serial block-face scanning electron microscopy.Clinical and experimental nephrology · 2019Article
- A Case of Podocytic Infolding Glomerulopathy with Primary Sjögren's Syndrome and Hashimoto's Thyroiditis.Chinese medical journal · 2018Article
- Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury.Scientific reports · 2016Article
- A case of podocytic infolding glomerulopathy with multiple myeloma.BMC nephrology · 2014Article
- A Case of Membranous Glomerulonephropathy Associated with Takayasu's Arteritis.Case reports in nephrology and urology · 2014Article
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Authors and funding
13 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA rare and peculiar glomerulopathy has begun to be recognized in Japan. The Japanese Society of Nephrology has established a research working group and has collected cases from all over Japan in an attempt to understand the complete spectrum of this glomerulopathy.
methodThe diagnostic criterion, which was needed to collect the cases, was proposed as a glomerulopathy showing microspheres or microtubular structures or both associated with podocytic infolding into the glomerular basement membrane (GBM) on electron microscopy. The lesion shows a non-argentaffin hole in the GBM with periodic acid methenamine silver staining and is similar to membranous glomerulonephritis.
resultsTwenty-five cases were collected from 17 institutions. Patients were 20-69 years old (19 women, 6 men). Seventeen patients also had collagen diseases such as lupus nephritis and Sjögren's syndrome. All patients had proteinuria. Proteinuria showed a remission in 15 of 23 patients within 12 months, but proteinuria remained higher than 1.0 g/day in five patients despite different types of therapy. Podocytic infolding including microspheres showed either positive or negative staining for immunoglobulins. Cluster formation of microspheres was found in 4 of 17 patients with collagen disease, and in five out eight patients without collagen disease. Electron-dense deposits in the GBM were also found in 6 of 17 patients with collagen disease but were not found in eight patients without collagen disease.
conclusionSome patients might have a subtype of lupus nephritis, class V, or membranous glomerulonephritis. However, we propose a new disease entity, podocytic infolding glomerulopathy, as a common basis of all 25 patients, because we suspect that microspheres or microtubular structures or both can be derived from podocytic infolding.
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