Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society2009
The Valsalva maneuver: screening for drug-induced baroreflex dysfunction.
Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Exploratory Biomarker Study of the Triple Reuptake Inhibitor SEP-432 Compared to the Dual Reuptake Inhibitor Duloxetine in Healthy Normal Subjects.CNS neuroscience & therapeutics · 2016Trial
- Hyperadrenergic postural tachycardia syndrome associated with augmented neurovascular transduction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Diastolic Blood Pressure Rise During Valsalva as a Surrogate for Sympathetic Activation to Identify Functional Hyperadrenergic Postural Tachycardia Syndrome.Research square · 2025Article
- Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Abnormal venous postural control: multiple sclerosis-specific change related to gray matter pathology or age-related neurodegenerative phenomena?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Vagal and Sympathetic Function in Neuropathic Postural Tachycardia Syndrome.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Active regulation of cerebral venous tone: simultaneous arterial and venous transcranial Doppler sonography during a Valsalva manoeuvre.European journal of applied physiology · 2010Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveMany drugs can interfere with baroreflex mechanisms thereby impairing blood pressure control, but few have undergone sufficient testing. The state of affairs may be explained by the lack of simple and inexpensive screening tests.
methodsIn eleven healthy men, we tested the hypothesis that a simple Valsalva maneuver could detect drug-induced changes in baroreflex function that have previously been described using more elaborate and invasive methodologies. They performed Valsalva maneuvers after selective pharmacological inhibition of the norepinephrine transporter (NET) in a placebo-controlled, double-blind, randomized, crossover fashion. Patients with severe autonomic failure served as positive controls.
resultsNET inhibition profoundly augmented the blood pressure decrease during phase II and attenuated the blood pressure overshoot in phase IV compared with placebo. Furthermore, NET inhibition increased the heart rate response during the Valsalva maneuver.
interpretationThe Valsalva maneuver recapitulated complex alterations in baroreflex regulation during NET inhibition. Thus, this simple and inexpensive test could be employed as a screening tool for drug-induced baroreflex dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.