ReviewLipids2008
From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway.
Review in Lipids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 93 citations in OpenAlex.
- Stable Isotopic Labeling of Dimethylallyl Pyrophosphate (DMAPP) Reveals Compartmentalization of Isoprenoid Biosynthesis during Sporulation inJournal of the American Chemical Society · 2025Article
- Gas Chromatography-Mass Spectrometry Metabolites and Transcriptome Profiling Reveal Molecular Mechanisms and Differences in Terpene Biosynthesis in TwoInternational journal of molecular sciences · 2024Article
- Advances in regulating vitamin KWorld journal of microbiology & biotechnology · 2023Review
- Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway.Frontiers in microbiology · 2023Article
- Secondary Terpenes inBiomedicines · 2022Review
- YdfD, a Lysis Protein of the Qin Prophage, Is a Specific Inhibitor of the IspG-Catalyzed Step in the MEP Pathway ofInternational journal of molecular sciences · 2022Article
- The Nonmevalonate Pathway of Isoprenoid Biosynthesis Supports Anaerobic Growth of Listeria monocytogenes.Infection and immunity · 2020Article
- C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins.Chemical science · 2015Article
- Metabolic engineering of Bacillus subtilis for terpenoid production.Applied microbiology and biotechnology · 2015Review
- Resistance-resistant antibiotics.Trends in pharmacological sciences · 2014Review
- Draft genome sequence of Rhodomicrobium udaipurense JA643T with special reference to hopanoid biosynthesis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.Angewandte Chemie (International ed. in English) · 2014Review
- The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.Bioorganic & medicinal chemistry letters · 2014Article
- Mechanistic aspects of carotenoid biosynthesis.Chemical reviews · 2014Review
- Article
- The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells.F1000Research · 2013Article
- Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus.Molecular biology reports · 2012Article
- Terpene biosynthesis: modularity rules.Angewandte Chemie (International ed. in English) · 2012Review
- An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis.Journal of the American Chemical Society · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigations on the biosynthesis of bacterial triterpenoids of the hopane series led to the unexpected discovery of an alternative mevalonate independent pathway for the formation of isoprene units. Methylerythritol phosphate, already presenting the C5 branched isoprene skeleton, is the key intermediate. This pathway was independently characterized in ginkgo embryos for the formation of diterpenoids. It is present in most bacteria and in the plastids of all organisms belonging to phototrophic phyla. The key steps of the discovery and elucidation of this metabolic route are presented in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.