ArticleJournal of anesthesia2008
Dopamine D2 receptor Taq IA polymorphism is associated with postoperative nausea and vomiting.
Article in Journal of anesthesia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Risk factors for postoperative nausea and vomiting after general anesthesia: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Genetic Factors Associated with Postoperative Nausea and Vomiting: a Systematic Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Pooled it
- Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management.Current issues in molecular biology · 2025Review
- The Neurometabolic Function of the Dopamine-Aminotransferase System.Metabolites · 2025Review
- OPRM1 A118G Polymorphism and Ondansetron Efficacy for Postoperative Nausea and Vomiting in Laparoscopic Gynaecological Surgery: A Retrospective Cohort Study.Therapeutics and clinical risk management · 2025Article
- Association of the dopamine D2 receptor gene SNP rs1800497 with postoperative nausea and vomiting: A prospective cohort study.European journal of anaesthesiology and intensive care · 2024Article
- Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting.Cancers · 2023Article
- The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia.Translational psychiatry · 2022Review
- Progress, Challenges, and Prospects of Research on the Effect of Gene Polymorphisms on Adverse Reactions to Opioids.Pain and therapy · 2022Review
- Genetic Susceptibility Toward Nausea and Vomiting in Surgical Patients.Frontiers in genetics · 2021Article
- Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.International journal of molecular sciences · 2019Article
- Potential role of pharmacogenomics testing in the setting of enhanced recovery pathways after surgery.Pharmacogenomics and personalized medicine · 2019Article
- Dopamine: Functions, Signaling, and Association with Neurological Diseases.Cellular and molecular neurobiology · 2019Review
- THE EFFECT OF ETHNICITY ON THE INCIDENCE OF POSTOPERATIVE NAUSEA AND VOMITING IN MODERATE TO HIGH RISK PATIENTS UNDERGOING GENERAL ANESTHESIA IN SOUTH AFRICA: A CONTROLLED OBSERVATIONAL STUDY.Middle East journal of anaesthesiology · 2017Observational
- Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer.Autonomic neuroscience : basic & clinical · 2017Article
- Postoperative nausea and vomiting.Korean journal of anesthesiology · 2014Review
- Genetic factors associated with pharmacotherapy and background sensitivity to postoperative and chemotherapy-induced nausea and vomiting.Experimental brain research · 2014Review
- Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting.Experimental brain research · 2014Article
- Musk shrews selectively bred for motion sickness display increased anesthesia-induced vomiting.Physiology & behavior · 2014Article
- Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting.European journal of pharmacology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe dopamine D2 receptor (DRD2) is considered to be involved in the development of postoperative nausea and vomiting (PONV). Our aim was to examine the relationship between DRD2 Taq IA polymorphism and the occurrence of PONV.
methodsWe enrolled 1070 patients who were scheduled to undergo elective surgery under general anesthesia. Patients who vomited or required rescue antiemetics for severe nausea at two time points (within 6 and within 24 h after surgery) were defined as having early and total PONV, respectively. A polymerase chain reaction with confronting two-pair primers (PCR-CTPP) technique was adopted for DRD2 genotyping allele (A1A1, A1A2, or A2A2). The relationship between DRD2 Taq IA polymorphism and the occurrence of PONV was examined by multivariate logistic regression analysis.
resultsThe incidences of early PONV were 9.0%, 9.3%, and 14.4% in patients with the A1A1, A1A2, and A2A2 alleles, respectively. Sex, nature of the disease, smoking status, type of surgical department, duration of anesthesia, and the DRD2 Taq IA polymorphism were related to the emergence of early PONV. On multivariate analysis, the relative risk associated with the A2A2 allele in comparison with the A1A1 or A1A2 allele was 1.58 (95% confidence interval [CI], 1.05-2.37) for early PONV. The incidences of total PONV were 12.5%, 13.6%, and 17.2% in patients with the A1A1, A1A2, and A2A2 alleles, respectively. Sex, smoking status, type of surgical department, and duration of anesthesia were related to the emergence of total PONV. On multivariate analysis, the relative risk associated with the A2A2 allele in comparison with the A1A1 or A1A2 allele was 1.27 (95% CI, 0.88-1.84) for total PONV.
conclusionThe DRD2 Taq IA polymorphism affected the occurrence of early PONV. Analysis of patients' genetic backgrounds may improve risk-stratification for PONV.
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