ArticlePloS one2008
Rapid experimental evolution of pesticide resistance in C. elegans entails no costs and affects the mating system.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 75 citations in OpenAlex.
- A proof-of-concept experimental-theoretical model to predict pesticide resistance evolution.Heredity · 2025Article
- Male frequency inEvolutionary applications · 2022Article
- Virus infection modulates male sexual behaviour in Caenorhabditis elegans.Molecular ecology · 2021Article
- Evaluating costs of heavy metal tolerance in a widely distributed, invasive butterfly.Evolutionary applications · 2021Article
- Local adaptation and rapid evolution of aphids in response to genetic interactions with their cottonwood hosts.Ecology and evolution · 2020Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- Predictability of the impact of multiple stressors on the keystone species Daphnia.Scientific reports · 2018Article
- A Model for Evolutionary Ecology of Disease: The Case forJournal of nematology · 2017Article
- Progression of phosphine resistance in susceptibleEvolutionary applications · 2017Article
- Adaptation costs to constant and alternating polluted environments.Evolutionary applications · 2017Article
- Fitness Effects of Thermal Stress Differ Between Outcrossing and Selfing Populations inEvolutionary biology · 2017Article
- Evolution of drug-tolerant nematode populations in response to density reduction.Evolutionary applications · 2016Article
- More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1.eLife · 2016Article
- Article
- Pollution breaks down the genetic architecture of life history traits in Caenorhabditis elegans.PloS one · 2015Article
- Rapid evolutionary responses of life history traits to different experimentally-induced pollutions in Caenorhabditis elegans.BMC evolutionary biology · 2014Article
- The ecology of sexual reproduction.Journal of evolutionary biology · 2014Review
- Ivermectin sensitivity is an ancient trait affecting all ecdysozoa but shows phylogenetic clustering among sepsid flies.Evolutionary applications · 2014Article
- Host adaptation to viruses relies on few genes with different cross-resistance properties.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mainstreaming Caenorhabditis elegans in experimental evolution.Proceedings. Biological sciences · 2014Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pesticide resistance is a major concern in natural populations and a model trait to study adaptation. Despite the importance of this trait, the dynamics of its evolution and of its ecological consequences remain largely unstudied. To fill this gap, we performed experimental evolution with replicated populations of Caenorhabditis elegans exposed to the pesticide Levamisole during 20 generations. Exposure to Levamisole resulted in decreased survival, fecundity and male frequency, which declined from 30% to zero. This was not due to differential susceptibility of males. Rather, the drug affected mobility, resulting in fewer encounters, probably leading to reduced outcrossing rates. Adaptation, i.e., increased survival and fecundity, occurred within 10 and 20 generations, respectively. Male frequency also increased by generation 20. Adaptation costs were undetected in the ancestral environment and in presence of Ivermectin, another widely-used pesticide with an opposite physiological effect. Our results demonstrate that pesticide resistance can evolve at an extremely rapid pace. Furthermore, we unravel the effects of behaviour on life-history traits and test the environmental dependence of adaptation costs. This study establishes experimental evolution as a powerful tool to tackle pesticide resistance, and paves the way to further investigations manipulating environmental and/or genetic factors underlying adaptation to pesticides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.