ArticleJournal of bacteriology2009
Trimeric autotransporters of Haemophilus parasuis: generation of an extensive passenger domain repertoire specific for pathogenic strains.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Effect of enrofloxacin in the carrier stage of Haemophilus parasuis in naturally colonized pigs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2014Trial
- Evidence for Genotype-Associated Differences in Disease Severity and Limitations of Serotype-Based Classification inPathogens (Basel, Switzerland) · 2026Article
- Genomic insights into diversity, antimicrobial resistance and virulence ofFrontiers in microbiology · 2025Article
- Epidemiology and pathogenicity ofFrontiers in microbiology · 2025Article
- Transcriptome analysis reveals a new virulence-associated trimeric autotransporter responsible for Glaesserella parasuis autoagglutination.Veterinary research · 2024Article
- Genomic insight into the diversity ofmSphere · 2024Article
- Molecular characterization of Glaesserella parasuis strains circulating in North American swine production systems.BMC veterinary research · 2023Article
- Molecular Characterization and Phylogenetic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- The long and the short of Periscope Proteins.Biochemical Society transactions · 2022Review
- Dosing Regimen of Aditoprim and Sulfamethoxazole Combination for thePharmaceutics · 2022Article
- Temporal Patterns of Phenotypic Antimicrobial Resistance and Coinfecting Pathogens inPathogens (Basel, Switzerland) · 2022Article
- Comparison of theFrontiers in veterinary science · 2021Article
- Article
- Non-adaptive Evolution of Trimeric Autotransporters inFrontiers in microbiology · 2020Article
- Haemophilus parasuis VtaA2 is involved in adhesion to extracellular proteins.Veterinary research · 2019Article
- Article
- Comparative genomic and methylome analysis of non-virulent D74 and virulent Nagasaki Haemophilus parasuis isolates.PloS one · 2018Article
- Molecular serotyping ofPeerJ · 2018Article
- "Pathotyping" Multiplex PCR Assay for Haemophilus parasuis: a Tool for Prediction of Virulence.Journal of clinical microbiology · 2017Article
- A robust PCR for the differentiation of potential virulent strains of Haemophilus parasuis.BMC veterinary research · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemophilus parasuis is the agent responsible for causing Glässer's disease, but little is known about the pathogenic determinants of this major pig disease. Here we describe, for the pathogenic strain Nagasaki, the molecular characterization of 13 trimeric autotransporters as assessed by the presence of YadA C-terminal translocator domains which were classified into three groups. All passenger domains possess motifs and repeats characteristic of adhesins, hemagglutinins, and invasins with various centrally located copies of collagen-like repeats. This domain architecture is shared with two trimeric autotransporter proteins of H. somnus 129Pt. Genomic comparison by microarray hybridization demonstrated homologies among H. parasuis virulent strains and high divergence with respect to nonvirulent strains. Therefore, these genes were named vtaA (virulence-associated trimeric autotransporters). The sequencing of 17 homologous vtaA genes of different invasive strains highlighted an extensive mosaic structure. Based also on the presence of DNA uptake signal sequences within the vtaA genes, we propose a mechanism of evolution by which gene duplication and the accumulation of mutations and recombinations, plus the lateral gene transfer of the passenger domain, led to the diversity of this multigene family. This study provides insights to help understand the tissue colonization and invasiveness characteristic of H. parasuis pathogenic strains.
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