ArticleJournal of bacteriology2009
Characterization of the myo-inositol utilization island of Salmonella enterica serovar Typhimurium.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Exometabolomic-enabled discovery of compounds associated with Escherichia coli O157:H7 population dynamics in the lettuce phyllosphere.BMC plant biology · 2026Article
- A culturomics approach reveals cross-feeding capacity of intestinal pig bacteria upon release of inositol from phytate.Microbiome · 2026Article
- Multi-omic stable isotope probing revealsISME communications · 2026Article
- Osmotic stress response of the coral and oyster pathogenApplied and environmental microbiology · 2024Article
- Hierarchic regulation of a metabolic pathway: H-NS, CRP, and SsrB controlMicrobiology spectrum · 2024Article
- Plasmid-encoded lactose metabolism and mobilized colistin resistance (Microbial genomics · 2023Article
- Genome-Wide Analysis ofAntibiotics (Basel, Switzerland) · 2023Article
- Metabolism in the Niche: a Large-Scale Genome-Based Survey Reveals Inositol Utilization To Be Widespread among Soil, Commensal, and Pathogenic Bacteria.Microbiology spectrum · 2022Review
- A diet-specific microbiota drives Salmonella Typhimurium to adapt its in vivo response to plant-derived substrates.Animal microbiome · 2021Article
- Staphylococcal Protein A (mSphere · 2020Article
- Whole-Genome-Based Survey for Polyphyletic Serovars ofInternational journal of molecular sciences · 2020Article
- The diversity, evolution and ecology of Salmonella in venomous snakes.PLoS neglected tropical diseases · 2019Article
- Transcriptome and Volatilome Analysis During Growth ofFrontiers in microbiology · 2019Article
- The small RNA RssR regulates myo-inositol degradation by Salmonella enterica.Scientific reports · 2018Article
- Comparative genomics of Salmonella enterica serovar Montevideo reveals lineage-specific gene differences that may influence ecological niche association.Microbial genomics · 2018Article
- Proteome remodelling by the stress sigma factor RpoS/σScientific reports · 2017Article
- Hysteresis in myo-inositol utilization by Salmonella Typhimurium.MicrobiologyOpen · 2017Article
- High binding affinity of repressor IolR avoids costs of untimely induction of myo-inositol utilization by Salmonella Typhimurium.Scientific reports · 2017Article
- Genetic Characterization of the Galactitol Utilization Pathway of Salmonella enterica Serovar Typhimurium.Journal of bacteriology · 2017Article
- Heat Survival and Phenotype Microarray Profiling of Salmonella Typhimurium Mutants.Current microbiology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knockout mutation of STM4432 resulted in a growth-deficient phenotype of Salmonella enterica serovar Typhimurium in the presence of myo-inositol (MI) as the sole carbon source. STM4432 is part of a 22.6-kb genomic island which spans STM4417 to STM4436 (genomic island 4417/4436) and is responsible for MI degradation. Genome comparison revealed the presence of this island in only six Salmonella strains and a high variability of the iol gene organization in gram-negative bacteria. Upon nonpolar deletion of 11 island loci, the genes involved in six enzymatic steps of the MI pathway were identified. The generation time of S. enterica serovar Typhimurium in minimal medium with MI decreases with higher concentrations of this polyol. Reverse transcriptase PCR showed five separate transcriptional units encompassing the genes iolA-iolB, iolE-iolG1, iolC1-iolC2, iolD1-iolD2-iolG2, and iolI2-iolH. Luciferase reporter assays revealed a strong induction of their promoters in the presence of MI but not glucose. The main regulator, IolR, was identified due to a reduced lag phase of a strain mutated in STM4417 (iolR). Deletion of iolR resulted in stimulation of the iol operons, indicating its negative effect on the iol genes of S. enterica serovar Typhimurium in rich medium at a transcriptional level. Bandshift assays demonstrated the binding of this putative repressor to promoter sequences of iolA, iolC1, and iolD1. Binding of IolR to its own promoter and induced iolR expression in an IolR-negative background demonstrate that its transcription is autoregulated. This is the first characterization of MI degradation in a gram-negative bacterium, revealing a complex transcriptional organization and regulation of the S. enterica serovar Typhimurium iol genes.
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