ArticleCancer research2008
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.
Article in Cancer research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance.Signal transduction and targeted therapy · 2025Article
- Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome.Science advances · 2024Article
- Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis.Cancers · 2017Review
- Do p53 stress responses impact organismal aging?Translational cancer research · 2016Article
- A mechanism for 1,4-Benzoquinone-induced genotoxicity.Oncotarget · 2016Article
- A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function.EMBO reports · 2016Article
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- Chromosomal Rearrangements in Cancer: Detection and potential causal mechanisms.Molecular & cellular oncology · 2014Article
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- Impact of the Ku complex on HIV-1 expression and latency.PloS one · 2013Article
- Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance.Cellular and molecular life sciences : CMLS · 2012Review
- Folate and colorectal cancer in rodents: a model of DNA repair deficiency.Journal of oncology · 2012Article
- Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.Oncogene · 2011Article
- Quantitative proteomic and interaction network analysis of cisplatin resistance in HeLa cells.PloS one · 2011Article
- Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.PloS one · 2011Article
- Towards inferring time dimensionality in protein-protein interaction networks by integrating structures: the p53 example.Molecular bioSystems · 2009Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Ku80 facilitates DNA repair and therefore should suppress cancer. However, ku80(-/-) mice exhibit reduced cancer, although they age prematurely and have a shortened life span. We tested the hypothesis that Ku80 deletion suppresses cancer by enhancing cellular tumor-suppressive responses to inefficiently repaired DNA damage. In support of this hypothesis, Ku80 deletion ameliorated tumor burden in APC(MIN) mice and increased a p53-mediated DNA damage response, DNA lesions, and chromosomal rearrangements. Thus, contrary to its assumed role as a caretaker tumor suppressor, Ku80 facilitates tumor growth most likely by dampening baseline cellular DNA damage responses.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.