ArticleCancer research2008
NOTCH is part of the transcriptional network regulating cell growth and survival in mouse plasmacytomas.
Article in Cancer research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Solitary hyoid plasmacytoma with unicentric Castleman disease: A case report and review of literature.World journal of clinical cases · 2022Article
- Prolactin synergizes with canonical Wnt signals to drive development of ER+ mammary tumors via activation of the Notch pathway.Cancer letters · 2021Article
- Associations of Autoimmunity, Immunodeficiency, Lymphomagenesis, and Gut Microbiota in Mice with Knockins for a Pathogenic Autoantibody.The American journal of pathology · 2017Article
- DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.Journal of autoimmunity · 2017Article
- Delta-like 4/Notch signaling promotes ApcBMC cancer · 2017Article
- Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.Molecular neurodegeneration · 2016Article
- Article
- IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma.The American journal of pathology · 2015Article
- Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis.Journal of cellular physiology · 2014Review
- Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC.Leukemia research · 2013Article
- GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.Leukemia · 2011Article
- IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells.PloS one · 2011Article
- Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases.The Journal of experimental medicine · 2010Article
- Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas.PloS one · 2010Article
- Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice.The Journal of pathology · 2010Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Aside from Myc-activating translocations characteristic of plasmacytomas (PCT), little is known about genetic factors and signaling pathways responsible for the development of spontaneous B-cell lineage lymphomas of mice. Here, we characterized the transcriptional profiles of PCT, centroblastic diffuse large B-cell lymphomas (CBL), and high-grade splenic marginal zone B-cell lymphoma (MZL++) using high-throughput quantitative reverse transcription-PCR. Expression profiles of CBL and MZL++ were strikingly similar and quite unlike that of PCT. Among the genes expressed at significantly higher levels by PCT were a number involved in NOTCH signaling, a finding supported by gene set enrichment analyses of microarray data. To investigate the importance of this pathway, NOTCH signaling was blocked in PCT cell lines by treatment with a gamma-secretase inhibitor (GSI) or transduction of a dominant-negative mutant of MAML1. These treatments resulted in reduced expression of NOTCH transcriptional targets in association with impaired proliferation and increased apoptosis. GSI treatment of transformed plasma cells in a primary PCT also induced apoptosis. These results integrate NOTCH activation with oncogenic signaling pathways downstream of translocated Myc in the pathogenesis of mouse PCT, two signaling pathways also implicated in development of human multiple myeloma and T-cell lymphoblastic lymphoma.
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