Trial reportMaturitas2008
Effects of estrogen versus estrogen and progesterone on cortisol and interleukin-6.
Trial report in Maturitas, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06497270 (A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery: the DISC-OVARY Trial
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Oral contraception but not menstrual cycle phase is associated with increased free cortisol levels and low hypothalamo-pituitary-adrenal axis reactivity.Journal of endocrinological investigation · 2013Trial
- Linking combined oral contraceptive use to systemic immune marker profiles: the role of cortisol.Frontiers in endocrinology · 2026Article
- Long-Term Effect of Early-Life Arsenic Exposure on Morning Plasma Cortisol in Adults from Antofagasta, Chile.medRxiv : the preprint server for health sciences · 2025Article
- Effects of gender-affirming hormones on diurnal cortisol concentrations: A prospective study.Neurobiology of stress · 2025Article
- Relationship between morphometric measurements and blood parameters in horses with varying adiposity levels and physiological conditions.Veterinary medicine and science · 2024Article
- Emerging Perspectives on the Impact of Diabetes Mellitus and Anti-Diabetic Drugs on Premenstrual Syndrome. A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Review
- Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause.The Journal of clinical endocrinology and metabolism · 2023Article
- The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions.Frontiers in endocrinology · 2023Review
- Associations of different hormonal contraceptive methods with hair concentrations of cortisol, cortisone, and testosterone in young women.Comprehensive psychoneuroendocrinology · 2022Article
- Adiposity Measures and Morning Serum Cortisol in African Americans: Jackson Heart Study.Obesity (Silver Spring, Md.) · 2021Article
- Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism.Cell reports · 2019Article
- Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression.Translational psychiatry · 2018Review
- Evaluating Stress during Pregnancy: Do We Have the Right Conceptions and the Correct Tools to Assess It?Journal of pregnancy · 2018Review
- Understanding Risky Behavior: The Influence of Cognitive, Emotional and Hormonal Factors on Decision-Making under Risk.Frontiers in psychology · 2017Review
- Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia.Progress in molecular biology and translational science · 2017Review
- Sex differences in the relationship of IL-6 signaling to cancer cachexia progression.Biochimica et biophysica acta · 2015Article
- EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone.Biochemical pharmacology · 2013Article
- Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.American journal of physiology. Endocrinology and metabolism · 2012Article
- Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease.Current drug metabolism · 2010Review
- Salivary cortisol as an alternative for serum cortisol in the low-dose adrenocorticotropic hormone stimulation test?Journal of endocrinological investigation · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThe purpose of this study was to compare the effects of 3 months of estrogen replacement therapy, estrogen plus progesterone replacement therapy and a placebo, on the resting cortisol and interleukin-6 (IL-6) levels in post-menopausal women.
methodsForty-three women were randomised to one of three treatment arms: estradiol 2mg/day (ERT), estradiol 2mg/day plus medroxyprogesterone acetate 5mg/day (HRT), or a placebo that was administered orally for 3 months.
resultsCortisol levels showed a significant condition by intervention interaction. Post hoc tests showed that ERT significantly increased cortisol levels after treatment compared to baseline, while in the HRT group a trend toward increased cortisol was found. No changes were observed in IL-6 levels.
conclusionsEstrogen administration elevated cortisol levels, but this effect may be moderated by progestins. IL-6 was not altered by ERT or HRT, future studies should consider the interaction of cortisol increases on change in IL-6 expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.