ArticleBiochemical and biophysical research communications2009
Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer.
Article in Biochemical and biophysical research communications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Prognostic value of CD166 expression in cancers of the digestive system: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Colorectal adenoma stem-like cell populations: associations with adenoma characteristics and metachronous colorectal neoplasia.Cancer prevention research (Philadelphia, Pa.) · 2013Trial
- The Role of Pan-Cytokeratin In Tumor Budding Upgrading In Malignant Colorectal Polyps At Stage pT1.Cancer management and research · 2025Article
- Article
- Possible role of ALDH1 and CD44 in lip carcinogenesis.Journal of applied oral science : revista FOB · 2023Article
- Assessing Putative Markers of Colorectal Cancer Stem Cells: From Colonoscopy to Gene Expression Profiling.Diagnostics (Basel, Switzerland) · 2022Article
- Lipid-Based Drug Delivery Nanoplatforms for Colorectal Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2020Review
- mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer.Yonsei medical journal · 2020Article
- Article
- A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells.Molecular cancer · 2017Article
- Racial disparity in colorectal cancer: Gut microbiome and cancer stem cells.World journal of stem cells · 2016Review
- Role of cancer stem cells in racial disparity in colorectal cancer.Cancer medicine · 2016Article
- Do we need colonoscopy verification in patients with fundic gland polyp?Intestinal research · 2016Article
- KRAS mutation associated with CD44/CD166 immunoexpression as predictors of worse outcome in metastatic colon cancer.Cancer biomarkers : section A of Disease markers · 2016Article
- When stem cells grow old: phenotypes and mechanisms of stem cell aging.Development (Cambridge, England) · 2016Review
- Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice.Gastroenterology · 2015Article
- Role of cancer stem cells in age-related rise in colorectal cancer.World journal of gastrointestinal pathophysiology · 2015Article
- miR-21 and miR-145 cooperation in regulation of colon cancer stem cells.Molecular cancer · 2015Article
- Characterization of LGR5 stem cells in colorectal adenomas and carcinomas.Scientific reports · 2015Article
- Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis.World journal of gastrointestinal pathophysiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
It is becoming increasingly evident that cancer stem cells play a vital role in development and progression of cancers and relapse following chemotherapy. The present study examines the presence of cancer stem-like cells (CSC) in adenomatous polyps and in normal appearing colonic mucosa in humans during aging. The number of polyps was found to increase linearly with advancing age (r(2)=0.92, p<0.02). Immunohistochemical analysis revealed co-localization of CSC markers CD44 and CD166 in colonic polyps. Real-time RT-PCR analysis of normal appearing mucosa from subjects with adenomatous polyps showed an age-related rise in CSC as evidenced by the increased expression of CD44, CD166 and ESA. A similar phenomenon was also observed for EGFR. In addition, the expression each CSC marker was found to be about 2-fold higher in subjects with 3-4 polyps than those with 1-2 polyps. In conclusion, our results show that colon cancer stem-like cells are present in the premalignant adenomatous polyps as well in normal appearing colonic mucosa. Moreover, our observation of the age-related rise in CSC in macroscopically normal colonic mucosa suggests a predisposition of the organ to developing colorectal cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.