ReviewAdvances in genetics2008
Genetics of the Framingham Heart Study population.
Review in Advances in genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.Aging · 2018Pooled it
- Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.PLoS genetics · 2016Pooled it
- Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.PloS one · 2015Pooled it
- Evidence for cost-effectiveness of lifestyle primary preventions for cardiovascular disease in the Asia-Pacific Region: a systematic review.Globalization and health · 2014Pooled it
- The MYH9/APOL1 region and chronic kidney disease in European-Americans.Human molecular genetics · 2011Pooled it
- Machine Learning for Coronary Heart Disease Prediction: Comparative Analysis of Framingham and Cleveland Subset of the UCI Dataset with SHAP-Based Interpretability.Epidemiologia (Basel, Switzerland) · 2026Article
- Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis.Genes · 2023Article
- Dairy Food Intake Is Not Associated With Frailty in Adults From the Framingham Heart Study.Journal of the Academy of Nutrition and Dietetics · 2023Article
- Multimodal Recruitment to Study Ovulation and Menstruation Health: Internet-Based Survey Pilot Study.Journal of medical Internet research · 2021Article
- Polygenic risk scores: pleiotropy and the effect of environment.GeroScience · 2020Article
- Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Nutrigenetics-personalized nutrition in obesity and cardiovascular diseases.International journal of obesity supplements · 2020Review
- Extended methods for gene-environment-wide interaction scans in studies of admixed individuals with varying degrees of relationships.Genetic epidemiology · 2019Article
- Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study.Experimental gerontology · 2018Article
- Article
- Analyzing metabolomics data for association with genotypes using two-component Gaussian mixture distributions.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2018Article
- Identification of polymorphisms in cancer patients that differentially affect survival with age.Aging · 2017Article
- Article
- Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.Journal of cachexia, sarcopenia and muscle · 2017Article
- Invited Commentary: The Framingham Offspring Study-A Pioneering Investigation Into Familial Aggregation of Cardiovascular Risk.American journal of epidemiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
This chapter provides an introduction to the Framingham Heart Study and the genetic research related to cardiovascular diseases conducted in this unique population. It briefly describes the origins of the study, the risk factors that contribute to heart disease, and the approaches taken to discover the genetic basis of some of these risk factors. The genetic architecture of several biological risk factors has been explained using family studies, segregation analysis, heritability, and phenotypic and genetic correlations. Many quantitative trait loci underlying cardiovascular diseases have been discovered using different molecular markers. Additionally, initial results from genome-wide association studies using 116,000 markers and the prospects of using 550,000 markers for association studies are presented. Finally, the use of this unique sample to study genotype and environment interactions is described.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.