ArticleWorld journal of gastroenterology2008
Effects of ghrelin on interdigestive contractions of the rat gastrointestinal tract.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond.IBRO neuroscience reports · 2022Review
- Xiangbinfang granules enhance gastric antrum motilityWorld journal of gastroenterology · 2021Article
- Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility.Frontiers in endocrinology · 2021Review
- Translating Developmental Principles to Generate Human Gastric Organoids.Cellular and molecular gastroenterology and hepatology · 2018Review
- Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake.Frontiers in endocrinology · 2018Review
- Electroacupuncture at ST25 inhibits jejunal motility: Role of sympathetic pathways and TRPV1.World journal of gastroenterology · 2016Article
- Ghrelin increases vagally mediated gastric activity by central sites of action.Neurogastroenterology and motility · 2014Article
- Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation.Journal of gastroenterology · 2014Article
- Role of ghrelin in the pathophysiology of gastrointestinal disease.Gut and liver · 2013Review
- Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity.The Journal of physiology · 2012Article
- Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Ghrelin - a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach.Frontiers in neuroscience · 2012Article
- Article
- Postoperative ileus: impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways.World journal of gastroenterology · 2010Review
- The prokinetic face of ghrelin.International journal of peptides · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ghrelin causes interdigestive contractions of the stomach in rats. However, it remains unknown whether ghrelin causes interdigestive contractions in the small intestine. Four strain gauge transducers were implanted on the antrum, duodenum, proximal and distal jejunum. After an overnight fast, gastrointestinal (GI) contractions were recorded in freely moving conscious rats. Spontaneous phase III-like contractions were observed at every 13-16 min in rat GI tract. The fasted motor patterns were replaced by the fed motor pattern immediately after food intake. Two minutes after finishing the spontaneous phase III-like contractions in the antrum, acyl ghrelin (0.8, 2.4 and 8.0 microg/kg per min) was continuously infused for 30 min. Three-five minutes after the starting ghrelin infusion, augmented phase III-like contractions were observed at the antrum, duodenum, and jejunum. Ghrelin infusion (0.8, 2.4 and 8.0 microg/kg per min) significantly increased motility index of phase III-like contractions at the antrum and jejunum in a dose dependent manner, compared to that of saline injection. Thus, it is likely that exogenously administered ghrelin causes phase III-like contraction at the antrum, which migrates to the duodenum and jejunum. The possible role of 5-HT, in addition to ghrelin, in mediating intestinal migrating motor complex (MMC), is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.