ArticleEuropean journal of immunology2008
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
Article in European journal of immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
- BAFF and APRIL Receptors in B Cell Immunity and Autoimmunity.Immunological reviews · 2026Review
- Gut Microbiota and Extraintestinal Cancers: Mechanistic Insights and Microbiome-Targeted Interventions.JGH open : an open access journal of gastroenterology and hepatology · 2026Review
- Nutrition and the gut microbiome: a symbiotic dialogue influencing health and disease.Frontiers in nutrition · 2026Review
- Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis.Frontiers in cardiovascular medicine · 2025Review
- Association of the gut microbiome with cancer immunotherapy.International journal of clinical oncology · 2023Review
- The gut microbiota: a double-edged sword in endometriosis†.Biology of reproduction · 2022Review
- Review
- GPR174 signals via GProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Microbiota and the Response to Vaccines Against Respiratory Virus.Frontiers in immunology · 2022Review
- Gut Microbiota and Immunotherapy.Frontiers in microbiology · 2022Review
- Gastrectomy impact on the gut microbiome in patients with gastric cancer: A comprehensive review.World journal of gastrointestinal surgery · 2021Review
- The Impact of SARS-CoV-2 on the Human Immune System and Microbiome.Infectious microbes & diseases · 2021Article
- Gut Microbiome Modulates Response to Cancer Immunotherapy.Digestive diseases and sciences · 2020Review
- Novel Insights of Lymphomagenesis ofCancers · 2019Review
- The Possible Role of Gut Microbiota and Microbial Translocation Profiling During Chemo-Free Treatment of Lymphoid Malignancies.International journal of molecular sciences · 2019Review
- Interrelation of Diet, Gut Microbiome, and Autoantibody Production.Frontiers in immunology · 2018Review
- Regulation of humoral immunity by gut microbial products.Gut microbes · 2017Article
- The thyroid, the eyes and the gut: a possible connection.Journal of endocrinological investigation · 2017Review
- Male Syrian Hamsters Experimentally Infected with Helicobacter spp. of the H. bilis Cluster Develop MALT-Associated Gastrointestinal Lymphomas.Helicobacter · 2016Article
- Probiotics as an Adjuvant Therapy in Major Depressive Disorder.Current neuropharmacology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Since enteric microbial composition is a distinctive and stable individual trait, microbial heterogeneity may confer lifelong, non-genetic differences between individuals. Here we report that C57BL/6 mice bearing restricted flora microbiota, a distinct but diverse resident enteric microbial community, are numerically and functionally deficient in marginal zone (MZ) B cells. Surprisingly, MZ B-cell levels are minimally affected by germ-free conditions or null mutations of various TLR signaling molecules. In contrast, MZ B-cell depletion is exquisitely dependent on cytolytic CD8(+) T cells, and includes targeting of a cross-reactive microbial/endogenous MHC class 1B antigen. Thus, members of certain enteric microbial communities link with CD8(+) T cells as a previously unappreciated mechanism that shapes innate immunity dependent on innate-like B cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.