Evidence map›Paper›PMID 19009353›Full record

ReviewNeuropsychology review2008

Can children with autism recover? If so, how?

Molly Helt, Elizabeth Kelley, Marcel Kinsbourne, Juhi Pandey, Hilary Boorstein, Martha Herbert, Deborah Fein

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Neuropsychology review, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 114 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02746445 completednot on this mapstarted 2016, after this paper: background citation

A Longitudinal Study on the Safety and Efficacy for Subjects With Autism Spectrum Disorder (ASD) Who Received Magnetic EEG/ECG-Guided Resonance Therapy (MeRT)

TypeobservationalSponsorWave NeuroscienceRan2016 to 2017Enrolled11ConditionsAutistic DisorderArmsNo intervention
NCT02758496 completednot on this mapstarted 2016, after this paper: background citation

A Chart Review to Evaluate the Safety and Efficacy of Magnetic EEG/ECG-Guided Resonance Therapy (MeRT) on Subjects With Autism Spectrum Disorder (ASD)

TypeobservationalSponsorWave NeuroscienceRan2016 to 2017Enrolled141ConditionsAutistic DisorderArmsMeRT Efficacy Chart Review
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 2 syntheses or guidelines pooled it, 349 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. The Behavioral Presentation of Autistic Adults in a Forensic Interview.Journal of autism and developmental disorders · 2026
    Article
  5. Article
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  9. Review
  10. The Neuroimmunology of Autism.Molecular neurobiology · 2025
    Review
  11. Article
  12. Associations between pragmatic language and Theory of Mind in individuals with a history of autism and those who have lost the autism diagnosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
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  20. Review

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Molly HeltDepartment of Psychology, University of Connecticut, Storrs, CT 06268, USA. molly.helt@uconn.edu
Elizabeth Kelley
Marcel Kinsbourne
Juhi Pandey
Hilary Boorstein
Martha Herbert
Deborah Fein
University of Connecticut · USCenter for Autism and Related Disorders · USMassachusetts General Hospital · USNew School · USQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although Autism Spectrum Disorders (ASD) are generally assumed to be lifelong, we review evidence that between 3% and 25% of children reportedly lose their ASD diagnosis and enter the normal range of cognitive, adaptive and social skills. Predictors of recovery include relatively high intelligence, receptive language, verbal and motor imitation, and motor development, but not overall symptom severity. Earlier age of diagnosis and treatment, and a diagnosis of Pervasive Developmental Disorder-Not Otherwise Specified are also favorable signs. The presence of seizures, mental retardation and genetic syndromes are unfavorable signs, whereas head growth does not predict outcome. Controlled studies that report the most recovery came about after the use of behavioral techniques. Residual vulnerabilities affect higher-order communication and attention. Tics, depression and phobias are frequent residual co-morbidities after recovery. Possible mechanisms of recovery include: normalizing input by forcing attention outward or enriching the environment; promoting the reinforcement value of social stimuli; preventing interfering behaviors; mass practice of weak skills; reducing stress and stabilizing arousal. Improving nutrition and sleep quality is non-specifically beneficial.

Indexed as

ChildAutistic DisorderHumansLanguage DevelopmentRecovery of FunctionStereotyped Behavior

Identifiers

PMID19009353
OpenAlexW1980505500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.