ArticleImmunogenetics2009
Lineage-specific diversification of killer cell Ig-like receptors in the owl monkey, a New World primate.
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Placing human gene families into their evolutionary context.Human genomics · 2022Review
- Rhesus Macaque Activating Killer Immunoglobulin-Like Receptors Associate With Fc Receptor Gamma (FCER1G) and Not With DAP12 Adaptor Proteins Resulting in Stabilized Expression and Enabling Signal Transduction.Frontiers in immunology · 2021Article
- Igh locus structure and evolution in Platyrrhines: new insights from a genomic perspective.Immunogenetics · 2020Article
- Co-evolution of MHC class I and variable NK cell receptors in placental mammals.Immunological reviews · 2015Review
- Co-evolution of the MHC class I and KIR gene families in rhesus macaques: ancestry and plasticity.Immunological reviews · 2015Review
- MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection.Frontiers in immunology · 2015Review
- Bimodal evolution of the killer cell Ig-like receptor (KIR) family in New World primates.Immunogenetics · 2013Article
- Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution.Nature reviews. Immunology · 2013Review
- Identification and diversity of killer cell Ig-like receptors in Aotus vociferans, a New World monkey.PloS one · 2013Article
- Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Revealing mammalian evolutionary relationships by comparative analysis of gene clusters.Genome biology and evolution · 2012Article
- Variable NK cell receptors exemplified by human KIR3DL1/S1.Journal of immunology (Baltimore, Md. : 1950) · 2011Review
- Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Primate-specific regulation of natural killer cells.Journal of medical primatology · 2010Review
- Article
- The mosaic of KIR haplotypes in rhesus macaques.Immunogenetics · 2010Article
- Comparative analysis of NK-cell receptor expression and function across primate species: Perspective on antiviral defenses.Self/nonself · 2010Article
- A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- A novel system of polymorphic and diverse NK cell receptors in primates.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Killer cell Ig-like receptors (KIRs) modulate the cytotoxic effects of natural killer cells. In primates, the KIRs are highly diverse as a consequence of variation in gene content, alternative domain composition, and loci polymorphism. We analyzed a bacterial artificial chromosome (BAC) clone draft sequence spanning the owl monkey KIR cluster. The draft sequence had seven ordered yet unconnected contigs containing six full-length and two partial gene models, flanked by the LILRB and FcAR framework genes. Gene models were predicted to encode KIRs with inhibitory, activating, or dual functionality. Four gene models encoded three Ig domain receptors, while three others encoded molecules with four Ig domains. The additional domain resulted from an insertion in tandem of a 2,101 bp fragment containing the last 289 bp of intron 2, exon 3, and intron 3, resulting in molecules with two D0 domains. Re-screening of the owl monkey BAC library and sequencing of partial cDNAs from an owl monkey yielded five additional KIRs, four of which encoded receptors with short cytoplasmic domains with premature stop codons due to either a single nucleotide substitution or deletion or the absence of exon 8. Phylogenetic analysis by domains showed that owl monkey KIRs were monophyletic, clustering independently from other primate KIR lineages. Retroelements found in introns, however, were shared by KIRs from different primate lineages. This suggests that the owl monkey inherited a KIR cluster with a rich history of exon shuffling upon which positive selection for ligand binding operated to diversify the receptors in a lineage-specific fashion.
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