ArticlePlant molecular biology2009
Identification and characterization of a hypoallergenic ortholog of Ara h 2.01.
Article in Plant molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 52 citations in OpenAlex.
- Design of an Ara h 2 hypoallergen from conformational epitopes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024Article
- Reverse genetic approaches for breeding nutrient-rich and climate-resilient cereal and food legume crops.Heredity · 2022Article
- Molecular evolution of genes encoding allergen proteins in the peanuts genus Arachis: Structural and functional implications.PloS one · 2019Article
- A Quantitative Method for Detecting Ara h 2 by Generation and Utilization of Monoclonal Antibodies.Journal of immunology research · 2018Article
- Quantitative trait loci from identification to exploitation for crop improvement.Plant cell reports · 2017Review
- Article
- TILLING by sequencing to identify induced mutations in stress resistance genes of peanut (Arachis hypogaea).BMC genomics · 2015Article
- Application of genomic tools in plant breeding.Current genomics · 2012Article
- TILLING: a shortcut in functional genomics.Journal of applied genetics · 2011Review
- TILLING for allergen reduction and improvement of quality traits in peanut (Arachis hypogaea L.).BMC plant biology · 2011Article
- EcoTILLING in Capsicum species: searching for new virus resistances.BMC genomics · 2010Article
- Article
- Mutagenesis and beyond! Tools for understanding legume biology.Plant physiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peanut (Arachis hypogaea L.), can elicit type I allergy becoming the most common cause of fatal food-induced anaphylactic reactions. Strict avoidance is the only effective means of dealing with this allergy. Ara h 2, a peanut seed storage protein, has been identified as the most potent peanut allergen and is recognized by approximately 90% of peanut hypersensitive individuals in the US. Because peanut has limited genetic variation, wild relatives are a good source of genetic diversity. After screening 30 Arachis duranensis accessions by EcoTILLing, we characterized five different missense mutations in ara d 2.01. None of these polymorphisms induced major conformational modifications. Nevertheless, a polymorphism in the immunodominant epitope #7 (S73T) showed a 56-99% reduction in IgE-binding activity and did not affect T cell epitopes, which must be retained for effective immunotherapy. The identification of natural hypoallergenic isoforms positively contributes to future immunological and therapeutic studies and peanut cultivar development.
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Registered trials
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