ArticlePLoS pathogens2008
The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- TPST Gene Knock-Out Eliminates Tyrosine Sulfation on a Recombinant Antibody Produced in CHO Cells.Biotechnology journal · 2026Article
- Transcriptomic analysis identifies hub genes involved in age-dependent abdominal fat development in chickens.Poultry science · 2026Article
- Correlation of 3'-phosphoadenosine-5'-phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous cell carcinoma.Histology and histopathology · 2023Article
- ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses.PLoS pathogens · 2021Article
- Sulfation pathways from red to green.The Journal of biological chemistry · 2019Review
- Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer.Oncotarget · 2016Review
- Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in primary human monocyte-derived macrophages.Virology journal · 2016Article
- Article
- CHD1 and CHD2 are positive regulators of HIV-1 gene expression.Virology journal · 2014Article
- ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter.PLoS pathogens · 2013Article
- 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthases, naturally fragile enzymes specifically stabilized by nucleotide binding.The Journal of biological chemistry · 2012Article
- MuLV IN mutants responsive to HDAC inhibitors enhance transcription from unintegrated retroviral DNA.Virology · 2012Article
- Evaluation of residual promoter activity in γ-retroviral self-inactivating (SIN) vectors.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.PloS one · 2012Article
- Systematic identification of novel, essential host genes affecting bromovirus RNA replication.PloS one · 2011Article
- Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.The Journal of biological chemistry · 2010Article
- Cellular transcription factor ZASC1 regulates murine leukemia virus transcription.Journal of virology · 2010Article
- Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.Chemical biology & drug design · 2010Article
- Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study.European journal of human genetics : EJHG · 2009Article
- Identification of novel host-oriented targets for Human Immunodeficiency Virus type 1 using Random Homozygous Gene Perturbation.Virology journal · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The early steps of retrovirus replication leading up to provirus establishment are highly dependent on cellular processes and represent a time when the virus is particularly vulnerable to antivirals and host defense mechanisms. However, the roles played by cellular factors are only partially understood. To identify cellular processes that participate in these critical steps, we employed a high volume screening of insertionally mutagenized somatic cells using a murine leukemia virus (MLV) vector. This approach identified a role for 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), one of two enzymes that synthesize PAPS, the high energy sulfate donor used in all sulfonation reactions catalyzed by cellular sulfotransferases. The role of the cellular sulfonation pathway was confirmed using chemical inhibitors of PAPS synthases and cellular sulfotransferases. The requirement for sulfonation was mapped to a stage during or shortly after MLV provirus establishment and influenced subsequent gene expression from the viral long terminal repeat (LTR) promoter. Infection of cells by an HIV vector was also shown to be highly dependent on the cellular sulfonation pathway. These studies have uncovered a heretofore unknown regulatory step of retroviral replication, have defined a new biological function for sulfonation in nuclear gene expression, and provide a potentially valuable new target for HIV/AIDS therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.