ArticleJournal of hypertension2008
Interactions between metallopeptidase 3 polymorphism rs679620 and BMI in predicting blood pressure in African-American women with hypertension.
Article in Journal of hypertension, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Trial
- The Association Between ThreeInternational journal of molecular sciences · 2025Article
- Review
- Novel Data about Association of the Functionally Significant Polymorphisms of the MMP9 Gene with Exfoliation Glaucoma in the Caucasian Population of Central Russia.Ophthalmic research · 2021Article
- Association of the matrix metalloproteinase-3 polymorphisms rs679620 and rs3025058 with ischemic stroke risk: a meta-analysis.Neuropsychiatric disease and treatment · 2018Article
- Improving -Omics-Based Research and Precision Health in Minority Populations: Recommendations for Nurse Scientists.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2018Review
- Article
- Article
- The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) Study: Design and Methods for Complex DNA Analysis.Biological research for nursing · 2016Article
- A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.Scientific reports · 2016Article
- A perspective for sequencing familial hypercholesterolaemia in African Americans.NPJ genomic medicine · 2016Article
- Body mass index modulates blood pressure heritability: the Family Blood Pressure Program.American journal of hypertension · 2014Article
- Cardiovascular genomics.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2013Review
- Alternative methods for measuring obesity in African American women.The Yale journal of biology and medicine · 2013Article
- Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT.International journal of hypertension · 2013Article
- Genetic and BMI risks for predicting blood pressure in three generations of West African Dogon women.Biological research for nursing · 2013Article
- Attitudes toward Genetic Testing for Hypertension among African American Women and Girls.Nursing research and practice · 2013Article
- Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.Journal of endodontics · 2012Article
- Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Current hypertension reports · 2012Review
- Gene-environment effects of SLC4A5 and skin color on blood pressure among African American women.Ethnicity & disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
BMI represents an internal metabolic and physiological environment that plays a key role in development of high blood pressure (BP) for many Americans. African-American women have a higher prevalence of high BP and being overweight than men or other ethnic groups. This study examines the genetic-environmental interaction effects of single nucleotide polymorphisms and BMI on BP among African-American women using 1418 African-American women and men from the Genetic Epidemiology Network of Arteriopathy study. A total of 403 tests of single nucleotide polymorphism-BMI interaction were conducted using methods of internal replication, cross-validation, and false discovery rate. One single nucleotide polymorphism (located in the ATP6B1 gene, rs2266917) passed adjustments for multiple testing and had a significant independent main effect (P = 0.0018) on diastolic BP among African-American women. A significant sex-specific interaction effect was found between MMP3_rs679620 and BMI in African-American women (P = 0.0009). MMP3_rs679620 (A-G polymorphism) encodes a Lys-Glu nonsynonymous variant at the 45th amino acid of metallopeptidase 3 and indicates a putative functional modification of metallopeptidase 3. These findings were not identified in African-American men. MMP3_rs679620 appears to have a protective effect on diastolic BP in women with high BMI. Surprisingly, MMP3_rs679620 had the opposite effect on women with low BMI, resulting in higher diastolic BP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.