ReviewArteriosclerosis, thrombosis, and vascular biology2009
The opening act: vasculogenesis and the origins of circulation.
Review in Arteriosclerosis, thrombosis, and vascular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation.Cellular and molecular life sciences : CMLS · 2025Article
- Article
- The effect of palm oil-derived tocotrienol-rich fraction in preserving normal retinal vascular diameter in streptozotocin-induced diabetic rats.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- VEGF Overexpression Significantly Increases Nanoparticle-Mediated siRNA Delivery and Target-Gene Downregulation.Pharmaceutics · 2022Article
- Human umbilical cord and its vessels: a histomorphometric study in difference severity of hypertensive disorders of pregnancy.Anatomy & cell biology · 2020Article
- Capillary rarefaction and altered renal development: the imbalance between pro- and anti-angiogenic factors in response to angiotensin II inhibition in the developing rat kidney.Journal of molecular histology · 2018Article
- Angiogenesis, Cancer, and Vascular Aging.Frontiers in cardiovascular medicine · 2017Review
- An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy.Scientific reports · 2016Article
- When it is better to regress: dynamics of vascular pruning.PLoS biology · 2015Article
- Expression of relative-protein of hypoxia-inducible factor-1α in vasculogenesis of mouse embryo.Journal of biological research (Thessalonike, Greece) · 2014Article
- Fox(y) regulators of VEGF receptors.Circulation research · 2014Article
- Angiopoietin-like protein 2 regulates endothelial colony forming cell vasculogenesis.Angiogenesis · 2014Article
- Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity.Frontiers in pharmacology · 2014Review
- Epigenetic programming and risk: the birthplace of cardiovascular disease?Stem cell reviews and reports · 2013Review
- Notch signalling in cardiovasculogenesis: insight into their role in early cardiovascular development.Molecular biology reports · 2013Article
- Ex vivo reconstitution of arterial endothelium by embryonic stem cell-derived endothelial progenitor cells in baboons.Stem cells and development · 2013Article
- Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development.Biochemical and biophysical research communications · 2013Article
- Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.PloS one · 2013Article
- Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments.Tissue engineering. Part A · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Previous studies on cellular and molecular mechanisms that regulate vascular development identified key signaling pathways and transcription factors. These findings supported the notion that the formation of vasculature is predominantly regulated by genetic programs, which is generally accepted. However, recent progress in understanding nongenetic factors that can modify the preprogrammed genetic mechanisms added another layer of complexity to our current understanding of vascular development. Here, we briefly summarize historic viewpoints and evolutionary perspectives on vascular development. We also review the cellular and molecular mechanisms that govern the emergence of the endothelial lineage and the subsequent process of vasculogenesis during development, with an emphasis on vascular endothelial growth factor and angiopoietin signaling cascades. Finally, we discuss epigenetic factors such as hemodynamic forces and hypoxic responses that can modulate and override the predetermined genetic mechanisms of vascular development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.