ArticleMolecular biology and evolution2009
Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 114 citations in OpenAlex.
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- Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective.Trends in neurosciences · 2025Review
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- Ancient and Nonuniform Loss of Olfactory Receptor Expression Renders the Shark Nose a De Facto Vomeronasal Organ.Molecular biology and evolution · 2023Article
- The PROUST hypothesis: the embodiment of olfactory cognition.Animal cognition · 2023Review
- Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents.Frontiers in nutrition · 2023Review
- Remarkable diversity of vomeronasal type 2 receptor (OlfC) genes of basal ray-finned fish and its evolutionary trajectory in jawed vertebrates.Scientific reports · 2022Article
- How the evolution of air breathing shaped hippocampal function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- A transcriptomic reevaluation of the accessory olfactory organ in Bichir (Polypterus senegalus).Zoological letters · 2022Article
- Olfactory-induced locomotion in lampreys.Cell and tissue research · 2022Review
- Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota.Frontiers in physiology · 2021Review
- Bitter taste receptors: Genes, evolution and health.Evolution, medicine, and public health · 2021Review
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Article
- Mitral cell development in the olfactory bulb of sharks: evidences of a conserved pattern of glutamatergic neurogenesis.Brain structure & function · 2019Article
- The Chemosensory Receptor Repertoire of a True Shark Is Dominated by a Single Olfactory Receptor Family.Genome biology and evolution · 2019Article
- Evolutionary ecology of chemosensation and its role in sensory drive.Current zoology · 2018Article
- Excreted Steroids in Vertebrate Social Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Comparative genomics provides a valuable tool for inferring the evolutionary history of physiological systems, particularly when this information is difficult to ascertain by morphological traits. One such example is the vomeronasal system (VNS), a vertebrate nasal chemosensory system that is responsible for detecting intraspecific pheromonal cues as well as environmental odorants. The morphological components of the VNS are found only in tetrapods, but the genetic components of the system have been found in teleost fish, in addition to tetrapods. To determine when the genetic components of the VNS originated, we searched for the VNS-specific genes in the genomes of two early diverging vertebrate lineages: the sea lamprey from jawless fishes and the elephant shark from cartilaginous fishes. Genes encoding vomeronasal type 1 receptors (V1Rs) and Trpc2, two components of the vomeronasal signaling pathway, are present in the sea lamprey genome, and both are expressed in the olfactory organ, revealing that the genetic components of the present-day VNS existed in the common ancestor of all extant vertebrates. Additionally, all three VNS genes, Trpc2, V1Rs, and vomeronasal type 2 receptors (V2Rs), are found in the elephant shark genome. Because V1Rs and V2Rs are related to two families of taste receptors, we also searched the early diverging vertebrate genomes for taste system genes and found them in the shark genome but not in the lamprey. Coupled with known distributions of the genetic components of the vertebrate main olfactory system, our results suggest staggered origins of vertebrate sensory systems. These findings are important for understanding the evolution of vertebrate sensory systems and illustrate the utility of the genome sequences of early diverging vertebrates for uncovering the evolution of vertebrate-specific traits.
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