ArticleMolecular biology and evolution2009
Rapid evolution and the importance of recombination to the gastroenteric pathogen Campylobacter jejuni.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed.
- AcceleratingProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sources of Human Campylobacteriosis Cases in Estonia and the Genomic Associations with Broiler Chicken Meat Isolates.Pathogens (Basel, Switzerland) · 2026Article
- Geographic clustering and population structures ofMicrobial genomics · 2026Article
- Genomic association of Campylobacter concisus for colonization advantages and virulence in children and adolescents with inflammatory bowel disease.BMC microbiology · 2026Article
- Epidemiology, antimicrobial resistance transmission, and One Health-based prevention of non-typhoidalFrontiers in microbiology · 2026Review
- Antimicrobial use onFrontiers in microbiology · 2026Article
- Identification of Novel Gene-Specific Markers for Differentiating Various PathogenicPathogens (Basel, Switzerland) · 2025Article
- Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comparative genomics and virulence potential of Campylobacter coli strains isolated from different sources over 25 years in Brazil.BMC microbiology · 2024Article
- Article
- Detecting co-selection through excess linkage disequilibrium in bacterial genomes.NAR genomics and bioinformatics · 2024Article
- Evolution of homologous recombination rates across bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Uncovering the boundaries ofmSystems · 2024Article
- Selection among site-dependent structurally constrained substitution models of protein evolution by approximate Bayesian computation.Bioinformatics (Oxford, England) · 2024Article
- Cj0683 Is a Competence Protein Essential for Efficient Initialization of DNA Uptake inBiomolecules · 2023Article
- Pan-Genome Analysis of Campylobacter: Insights on the Genomic Diversity and Virulence Profile.Microbiology spectrum · 2022Article
- phastSim: Efficient simulation of sequence evolution for pandemic-scale datasets.PLoS computational biology · 2022Article
- Cryptic Prophages Contribution forMicroorganisms · 2022Article
- Zoonotic Transmission ofFrontiers in microbiology · 2022Article
- phastSim: efficient simulation of sequence evolution for pandemic-scale datasets.bioRxiv : the preprint server for biology · 2021Article
44 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Responsible for the majority of bacterial gastroenteritis in the developed world, Campylobacter jejuni is a pervasive pathogen of humans and animals, but its evolution is obscure. In this paper, we exploit contemporary genetic diversity and empirical evidence to piece together the evolutionary history of C. jejuni and quantify its evolutionary potential. Our combined population genetics-phylogenetics approach reveals a surprising picture. Campylobacter jejuni is a rapidly evolving species, subject to intense purifying selection that purges 60% of novel variation, but possessing a massive evolutionary potential. The low mutation rate is offset by a large effective population size so that a mutation at any site can occur somewhere in the population within the space of a week. Recombination has a fundamental role, generating diversity at twice the rate of de novo mutation, and facilitating gene flow between C. jejuni and its sister species Campylobacter coli. We attempt to calibrate the rate of molecular evolution in C. jejuni based solely on within-species variation. The rates we obtain are up to 1,000 times faster than conventional estimates, placing the C. jejuni-C. coli split at the time of the Neolithic revolution. We weigh the plausibility of such recent bacterial evolution against alternative explanations and discuss the evidence required to settle the issue.
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