ReviewMolecular endocrinology (Baltimore, Md.)2009
Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism.
Review in Molecular endocrinology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 99 citations in OpenAlex.
- 4-Octyl Itaconate Attenuates Age-Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Sex difference in BAT thermogenesis depends on PGC-1α-mediated phospholipid synthesis in mice.Nature communications · 2025Article
- ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases.Signal transduction and targeted therapy · 2023Review
- Article
- Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Importance of adipocyte browning in the evolution of endothermy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.Genes & development · 2018Article
- Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression.Cellular oncology (Dordrecht, Netherlands) · 2018Review
- Emerging role of circadian clock disruption in alcohol-induced liver disease.American journal of physiology. Gastrointestinal and liver physiology · 2018Review
- Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells.Cell death & disease · 2018Article
- Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression.Cellular signalling · 2017Article
- Brown and Beige Adipose Tissues in Health and Disease.Comprehensive Physiology · 2017Review
- Novel Polymorphisms of Adrenergic, Alpha-1B-, Receptor and Peroxisome Proliferator-activated Receptor Gamma, Coactivator 1 Beta Genes and Their Association with Egg Production Traits in Local Chinese Dagu Hens.Asian-Australasian journal of animal sciences · 2016Article
- PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells.Mediators of inflammation · 2016Article
- Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism.Nutrition & metabolism · 2016Review
- Rethinking the paradigm: How comparative studies on fatty acid oxidation inform our understanding of T cell metabolism.Molecular immunology · 2015Review
- Article
- Differential effects of short-term β agonist and growth hormone treatments on expression of myosin heavy chain IIB and associated metabolic genes in sheep muscle.Animal : an international journal of animal bioscience · 2015Article
- PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Transcriptional coactivators and corepressors are emerging as important regulators of energy metabolism and other biological processes. These factors exert their effects on the transcription of target genes through interaction with selective transcription factors and the recruitment of chromatin-remodeling complexes. Recent genetic and biochemical analyses of the peroxisomal proliferator-activated receptor-gamma coactivator 1 networks provide novel mechanistic insights regarding their role in the control of mitochondrial oxidative metabolism. These coactivators integrate tissue metabolic functions in response to nutritional signals as well as circadian timing cues. In contrast to coactivators, transcriptional corepressors have been demonstrated to play an opposite role in the control of mitochondrial biogenesis and respiration. The balance of these coactivator and corepressor proteins and, more importantly, their access to specific transcriptional partners are predicted to dictate the epigenetic states of target genes as well as the metabolic phenotype of the cells. This review highlights the biological role and mechanistic basis of the peroxisomal proliferator-activated receptor-gamma coactivator 1 networks in the regulation of chromatin-remodeling and mitochondrial oxidative metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.