ArticleCerebral cortex (New York, N.Y. : 1991)2009
Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- Changing subplate circuits: Early activity dependent circuit plasticity.Frontiers in cellular neuroscience · 2022Pooled it
- A topographic protomap in mouse subplate neurons precedes the onset of sensory experience.Nature communications · 2026Article
- Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons.Journal of anatomy · 2026Article
- Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitors.bioRxiv : the preprint server for biology · 2026Article
- A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus.bioRxiv : the preprint server for biology · 2025Article
- A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex.Cell reports · 2025Article
- The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer.Open medicine (Warsaw, Poland) · 2025Article
- Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven cortical activation.Frontiers in neuroanatomy · 2025Article
- Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development.bioRxiv : the preprint server for biology · 2024Article
- ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.EMBO reports · 2024Article
- Distinct distribution of subplate neuron subtypes between the sensory cortices during the early postnatal period.The Journal of comparative neurology · 2024Article
- Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.Cell reports · 2023Article
- Highly branched and complementary distributions of layer 5 and layer 6 auditory corticofugal axons in mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Cortical Layer Markers Expression and Increased Synaptic Density in Interstitial Neurons of the White Matter from Drug-Resistant Epilepsy Patients.Brain sciences · 2023Article
- Temporal origin of mouse claustrum and development of its cortical projections.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Experience-dependent functional plasticity and visual response selectivity of surviving subplate neurons in the mouse visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
32 more citing papers are in PubMed but not listed here.
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11 authors at 5 institutions in 3 countries.
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Abstract
The subplate lays the foundation of the developing cerebral cortex, and abnormalities have been suggested to contribute to various brain developmental disorders. The causal relationship between cellular pathologies and cognitive disorders remains unclear, and therefore, a better understanding of the role of subplate cells in cortical development is essential. Only by determining the molecular taxonomy of this diverse class of neurons can we identify the subpopulations that may contribute differentially to cortical development. We identified novel markers for murine subplate cells by comparing gene expression of subplate and layer 6 of primary visual and somatosensory cortical areas of postnatal day (P)8 old mice using a microarray-based approach. We examined the utility of these markers in well-characterized mutants (reeler, scrambler, and p35-KO) where the subplate is displaced in relation to the cortical plate. In situ hybridization or immunohistochemistry confirmed subplate-selective expression of complexin 3, connective tissue growth factor, nuclear receptor-related 1/Nr4a2, and monooxygenase Dbh-like 1 while transmembrane protein 163 also had additional expression in layer 5, and DOPA decarboxylase was also present in the white matter. Localization of marker-positive cells in the reeler and p35-KO cortices suggests different subpopulations of subplate cells. These new markers open up possibilities for further identification of subplate subpopulations in research and in neuropathological diagnosis.
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