ArticleProceedings of the National Academy of Sciences of the United States of America2008
Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 70 citations in OpenAlex.
- Review
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- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
- Prenatal Hypoxia Induces ClFrontiers in physiology · 2022Article
- Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression.Frontiers in physiology · 2021Article
- Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation.Neuron · 2020Article
- Respiratory regulation & interactions with neuro-cognitive circuitry.Neuroscience and biobehavioral reviews · 2020Review
- Differential impact of two critical respiratory centres in opioid-induced respiratory depression in awake mice.The Journal of physiology · 2020Article
- The Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity.Trends in neurosciences · 2019Review
- Neural network model of an amphibian ventilatory central pattern generator.Journal of computational neuroscience · 2019Article
- Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Efficient Coding and Energy Efficiency Are Promoted by Balanced Excitatory and Inhibitory Synaptic Currents in Neuronal Network.Frontiers in cellular neuroscience · 2018Article
- Different roles for inhibition in the rhythm-generating respiratory network.Journal of neurophysiology · 2017Article
- Computational models of the neural control of breathing.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Emergent Network Topology within the Respiratory Rhythm-Generating Kernel Evolved In Silico.PloS one · 2016Article
- Neural Control of Breathing and CO2 Homeostasis.Neuron · 2015Review
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
Inspiratory and expiratory rhythms in mammals are thought to be generated by pacemaker-like neurons in 2 discrete brainstem regions: pre-Bötzinger complex (preBötC) and parafacial respiratory group (pFRG). How these putative pacemakers or pacemaker networks may interact to set the overall respiratory rhythm in synchrony remains unclear. Here, we show that a pacemakers 2-way "handshake" process comprising pFRG excitation of the preBötC, followed by reverse inhibition and postinhibitory rebound (PIR) excitation of the pFRG and postinspiratory feedback inhibition of the preBötC, can provide a phase-locked mechanism that sequentially resets and, hence, synchronizes the inspiratory and expiratory rhythms in neonates. The order of this handshake sequence and its progression vary depending on the relative excitabilities of the preBötC vs. the pFRG and resultant modulations of the PIR in various excited and depressed states, leading to complex inspiratory and expiratory phase-resetting behaviors in neonates and adults. This parsimonious model of pacemakers synchronization and mutual entrainment replicates key experimental data in vitro and in vivo that delineate the developmental changes in respiratory rhythm from neonates to maturity, elucidating their underlying mechanisms and suggesting hypotheses for further experimental testing. Such a pacemakers handshake process with conjugate excitation-inhibition and PIR provides a reinforcing and evolutionarily advantageous fail-safe mechanism for respiratory rhythmogenesis in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.