ArticleMicrobes and infection2009
Trehalose 6,6'-dimycolate on the surface of Mycobacterium tuberculosis modulates surface marker expression for antigen presentation and costimulation in murine macrophages.
Article in Microbes and infection, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- PPE57 Cooperates with MmpL3 to Mediate Bacterial Lipid Transport and Promote Persistent Infection ofMicroorganisms · 2026Article
- Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies ofMedComm · 2026Review
- Distributable, metabolic PET reporting of tuberculosis.Nature communications · 2024Article
- From pathogenesis to antigens: the key to shaping the future of TB vaccines.Frontiers in immunology · 2024Review
- Insights into the molecular determinants involved inVirulence · 2021Review
- Generation of Liposomes to Study the Effect ofInternational journal of molecular sciences · 2021Article
- The Pathogenesis of Tuberculosis-The Koch Phenomenon Reinstated.Pathogens (Basel, Switzerland) · 2020Review
- Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection.Immune network · 2020Review
- Fighting Persistence: How Chronic Infections with Mycobacterium tuberculosis Evade T Cell-Mediated Clearance and New Strategies To Defeat Them.Infection and immunity · 2020Review
- Mycobacterial Trehalose 6,6'-Dimycolate-Induced M1-Type Inflammation.The American journal of pathology · 2020Article
- RecombinantExperimental and therapeutic medicine · 2017Article
- Macrophages in tuberculosis: friend or foe.Seminars in immunopathology · 2013Review
- Disruption of immune regulation by microbial pathogens and resulting chronic inflammation.Journal of cellular physiology · 2013Review
- Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis.Frontiers in immunology · 2013Article
- Nocardia brasiliensis cell wall lipids modulate macrophage and dendritic responses that favor development of experimental actinomycetoma in BALB/c mice.Infection and immunity · 2012Article
- Differential effects of Mycobacterium bovis--derived polar and apolar lipid fractions on bovine innate immune cells.Veterinary research · 2012Article
- Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis.Clinical & developmental immunology · 2012Review
- Manipulation of costimulatory molecules by intracellular pathogens: veni, vidi, vici!!PLoS pathogens · 2012Review
- Pathogenesis, immunology, and diagnosis of latent Mycobacterium tuberculosis infection.Clinical & developmental immunology · 2011Review
- New approaches in the diagnosis and treatment of latent tuberculosis infection.Respiratory research · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Trehalose 6,6'-dimycolate (TDM) is the most abundant lipid extracted from Mycobacterium tuberculosis (MTB). TDM promotes MTB survival by decreasing phagosomal acidification and phagolysosomal fusion in macrophages. Delipidation of MTB using petroleum ether removes TDM and decreases MTB survival within host cells. TDM reconstituted onto MTB restores its virulent wild-type characteristics. We investigated the role of TDM in regulating surface marker expression in MTB-infected macrophages. Macrophages were infected with wild-type, delipidated, and TDM-reconstituted MTB for 24h and measured for changes in surface marker expression. TDM on MTB was found to specifically target MHCII, CD1d, CD40, CD80 and CD86. Both wild-type and TDM-reconstituted MTB suppressed or induced no change in expression of these surface markers, whereas delipidated MTB increased expression of the same markers. MTB-infected macrophages were also overlaid with MHCII-restricted T cell hybridomas which recognize Antigen 85B. Macrophages infected by wild-type and TDM-reconstituted MTB did not present antigen as well as delipidated MTB-infected macrophages. The evidence shown furthers supports the notion that TDM present on MTB promotes its survival and persistence in host macrophages.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.