ArticleClinical and experimental immunology1991
Modulation of Mycobacterium avium growth in vivo by cytokines: involvement of tumour necrosis factor in resistance to atypical mycobacteria.
Article in Clinical and experimental immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis.Infection and immunity · 2001Article
- Minor role played by type I tumour necrosis factor receptor in the control of Mycobacterium avium proliferation in infected mice.Immunology · 2000Article
- The modulating effects of proinflammatory cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), and immunoregulating cytokines IL-10 and transforming growth factor-beta (TGF-beta), on anti-microbial activity of murine peritoneal macrophages against Mycobacterium avium-intracellulare complex.Clinical and experimental immunology · 1999Article
- Inhibition of tumor necrosis factor alpha alters resistance to Mycobacterium avium complex infection in mice.Antimicrobial agents and chemotherapy · 1998Article
- Interleukin-12 in infectious diseases.Clinical microbiology reviews · 1997Review
- Mycobacterium avium infection in mice is associated with time-related expression of Th1 and Th2 CD4+ T-lymphocyte response.Immunology · 1997Article
- Temporal effect of tumor necrosis factor alpha on murine macrophages infected with Mycobacterium avium.Infection and immunity · 1997Article
- Evidence for a reduced chemokine response in the lungs of beige mice infected with Mycobacterium avium.Immunology · 1997Article
- Effects of benzoxazinorifamycin KRM-1648 on cytokine production at sites of Mycobacterium avium complex infection induced in mice.Antimicrobial agents and chemotherapy · 1997Article
- Cytokine secretion and adhesion molecule expression by granuloma T lymphocytes in Mycobacterium avium infection.The American journal of pathology · 1996Article
- Immunopathology of tuberculosis: roles of macrophages and monocytes.Infection and immunity · 1996Review
- Relationship between virulence of Mycobacterium avium strains and induction of tumor necrosis factor alpha production in infected mice and in in vitro-cultured mouse macrophages.Infection and immunity · 1995Article
- Protection of mice from Mycobacterium avium infection by recombinant interleukin-12.Antimicrobial agents and chemotherapy · 1995Article
- Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection.Infection and immunity · 1994Article
- Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages.Immunology · 1993Article
- Differential expression of tumor necrosis factor and interleukin-6 by peritoneal macrophages in vivo and in culture.The American journal of pathology · 1993Article
- Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.Infection and immunity · 1993Article
- Capacity of Mycobacterium avium isolates to grow well or poorly in murine macrophages resides in their ability to induce secretion of tumor necrosis factor.Infection and immunity · 1992Article
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1 author.
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Abstract
The protective mechanisms associated with resistance to atypical mycobacteria infections are not clear. In an effort to broaden our understanding of the mechanisms involved, susceptible mice were infected with a virulent strain of M. avium and various treatments were applied so as to modify the course of the disease. Treatment with an antiserum against tumour necrosis factor-alpha (TNF-alpha) significantly enhanced the experimental infection, as judged by enumeration of colony-forming units (CFU) in the spleens and livers of infected mice, suggesting a role for TNF-alpha in resistance to M. avium. In other sets of experiments, recombinant cytokines were directly infused into infected mice. Infusion of recombinant interferon-gamma (IFN-gamma) did not modify the experimental infection significantly, and infusion of interleukin-2 was also without effect. Injection of TNF-alpha enhanced resistance in susceptible animals, as seen by a reduction in the viable bacilli recovered from the spleens and livers. In a final set of experiments, we demonstrate that combinations of cytokines may induce strong resistance against M. avium, namely injection of 1 micrograms of interleukin-1 alpha and 1 micrograms of TNF-alpha at 5-day intervals which was seen to eradicate M. avium in both spleens and livers of susceptible BALB/c mice. Overall, our results suggest that induction of protection against M. avium by treatment with cytokines may be feasible, and that TNF-alpha may be a pivotal molecule in resistance to M. avium.
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