ArticleImmunity2008
Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
Article in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
101 citing papers in PubMed, 166 citations in OpenAlex.
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- By dawn or dusk-how circadian timing rewrites bacterial infection outcomes.FEBS letters · 2026Review
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Listeriosis.Nature reviews. Disease primers · 2025Review
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- Steady-state, therapeutic, and helminth-induced IL-4 compromise protective CD8 T cell bystander activation.bioRxiv : the preprint server for biology · 2024Article
- Networked Cluster Formation via Trigonal Lipid Modules for Augmented Ex Vivo NK Cell Priming.International journal of molecular sciences · 2024Article
- Recognition ofInnate immunity · 2023Review
- The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse.The EMBO journal · 2023Article
- VNN1 as a potential biomarker for sepsis diagnosis and its implications in immune infiltration and tumor prognosis.Frontiers in medicine · 2023Article
- Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model.Cell death discovery · 2022Article
- Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.Immunity · 2022Article
- Signals governing monocyte differentiation during inflammation.Current opinion in immunology · 2021Review
- The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Associations of Serum S100A12 With Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Prospective Cohort Study.Frontiers in immunology · 2021Article
- A Novel Anti-Infective Peptide BCCY-1 With Immunomodulatory Activities.Frontiers in immunology · 2021Article
- DCs-based therapies: potential strategies in severe SARS-CoV-2 infection.International journal of medical sciences · 2021Review
- CXCR3 enables recruitment and site-specific bystander activation of memory CD8Nature communications · 2019Article
- Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor.Journal for immunotherapy of cancer · 2019Article
- IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8αImmunity · 2019Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
An early granulomatous response, characterized by collections of white blood cells at foci surrounding pathogens, occurs after infection by many intracellular organisms, including Listeria, but how these clusters become organized and for what purpose remain poorly understood. Here, we showed that dendritic cell (DC) activation by Listeria nucleated rapid clustering of innate cells, including granulocytes, natural killer (NK) cells, and monocytes, to sites of bacteria propagation where interleukin-12 was expressed in the spleen. Clustered NK cells expressed interferon-gamma (IFN-gamma), which was necessary for the activation and maturation of colocalized monocytes to tumor necrosis factor- and inducible nitric oxide synthase-producing DCs (TipDCs). NK cell clustering was necessary for IFN-gamma production and required pertussis-toxin-sensitive recruitment, in part mediated by the chemokine receptor CCR5, and MyD88 adaptor-mediated signaling. Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.