ArticleClinical immunology (Orlando, Fla.)2009
Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis.
Article in Clinical immunology (Orlando, Fla.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- IL-8 Secreted by Gastric Epithelial Cells Infected withViruses · 2023Article
- CCR6 activation links innate immune responses to mucosa-associated lymphoid tissue lymphoma development.Haematologica · 2022Article
- Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments.Journal of immunology research · 2020Article
- A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer.EBioMedicine · 2019Article
- A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.PloS one · 2016Article
- Curcumin inhibits gastric inflammation induced by Helicobacter pylori infection in a mouse model.Nutrients · 2015Article
- Article
- Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.PloS one · 2014Article
- IL-22 negatively regulates Helicobacter pylori-induced CCL20 expression in gastric epithelial cells.PloS one · 2014Article
- Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA.Iranian journal of microbiology · 2013Article
- Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection.Journal of clinical immunology · 2012Article
- Article
- Enhanced expression of CXCL13 in human Helicobacter pylori-associated gastritis.Digestive diseases and sciences · 2011Article
- Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells.Digestive diseases and sciences · 2011Article
- Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology.Cellular & molecular immunology · 2010Review
- Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses.Infection and immunity · 2010Article
- Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
CC chemokine ligand 20 (CCL20) attracts CC chemokine receptor 6 (CCR6)-expressing cells. Using endoscopic biopsies taken from the gastric antrum of 42 subjects infected with H. pylori and 42 uninfected subjects, mucosal CCL20 mRNA and protein levels were measured by real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. CCL19 mRNA and protein levels, as well as CCL21 mRNA levels, were also measured. The CCL20 mRNA and protein levels were significantly elevated in H. pylori-positive patients and substantially decreased after successful eradication. CCL19 and CCL21 expression levels were comparable in the H. pylori-infected and the uninfected groups. The CCL20 concentrations correlated with the degree of chronic gastritis. Immunohistochemistry and the in vitro infection assay showed that CCL20 was principally produced by the gastric epithelium. CCR6-expressing cells, including CD45RO(+) memory T lymphocytes and fascin(+)-CD1a(+) immature dendritic cells, infiltrated close to the CCL20-expressing epithelial cells. The CCL20/CCR6 interaction may be involved in the development of H. pylori-associated gastritis.
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Registered trials
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