ArticleStress (Amsterdam, Netherlands)2009
Estrogen prevents norepinephrine alpha-2a receptor reversal of stress-induced working memory impairment.
Article in Stress (Amsterdam, Netherlands), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Alpha-2 Adrenergic Agonists Reduce Heavy Alcohol Drinking and Improve Cognitive Performance in Mice.eNeuro · 2026Article
- Sex-dependent effects of multiple acute concurrent stresses on memory: a role for hippocampal estrogens.Frontiers in behavioral neuroscience · 2022Article
- In search of sex-related mediators of affective illness.Biology of sex differences · 2021Review
- Examining the role of ovarian hormones in the association between worry and working memory across the menstrual cycle.Psychoneuroendocrinology · 2021Article
- Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics.International review of neurobiology · 2021Article
- Targeting the Glucocorticoid Receptors During Alcohol Withdrawal to Reduce Protracted Neurocognitive Disorders.Frontiers in psychiatry · 2019Review
- Sex differences in stress reactivity in arousal and attention systems.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions.Frontiers in psychiatry · 2019Review
- Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress.Brain research · 2016Review
- Reproductive Steroid Regulation of Mood and Behavior.Comprehensive Physiology · 2016Review
- Oestradiol modulation of cognition in adult female marmosets (Callithrix jacchus).Journal of neuroendocrinology · 2014Article
- Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex.Frontiers in human neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding effects of estrogen on the medial prefrontal cortex (PFC) may help to elucidate the increased prevalence of depression and post-traumatic stress disorder in women of ovarian cycling age. Estrogen replacement in ovariectomized (OVX) young rats amplifies the detrimental effects of stress on working memory (a PFC-mediated task), but the mechanisms by which this occurs have yet to be identified. In male rats, stimulation of norepinephrine alpha-2 adrenoceptors protects working memory from stress-induced impairments. However, this effect has not been studied in females, and has not been examined for sensitivity to estrogen. The current study asked whether OVX females with estrogen replacement (OVX+Est) and without replacement (OVX+Veh) responded differently to stimulation of alpha-2 adrenoceptors after administration of the benzodiazepine inverse agonist FG7142, a pharmacological stressor. The alpha-2 agonist, guanfacine, protected working memory from the impairing effects of FG7142 in OVX+Veh, but not in OVX+Est rats. Western Blot analysis for alpha-2 receptors was performed on PFC tissue from each group, but no changes in expression were found, indicating that the behavioral effects observed were likely not due to changes in receptor expression. These findings point to possible mechanisms by which estrogen may enhance the stress response, and hold implications for the gender discrepancy in the prevalence of stress-related mental illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.