ArticleParasitology research2009
Eimeria vermiformis infection reduces goblet cells by multiplication in the crypt cells of the small intestine of C57BL/6 mice.
Article in Parasitology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Anticoccidial and Antioxidant Activities of an Ethanolic Extract ofVeterinary sciences · 2024Article
- Fighting eimeriosis by using the anti-eimerial and anti-apoptotic properties of rhatany root extract.Frontiers in immunology · 2024Article
- Alterations in the jejunal microbiota and fecal metabolite profiles of rabbits infected with Eimeria intestinalis.Parasites & vectors · 2022Article
- Article
- Dietary supplementation with free methionine or methionine dipeptide improves environment intestinal of broilers challenged with Eimeria spp.Journal of animal science · 2019Article
- X-ray evaluation of intestinal dysmotility induced by Eimeria pragensis infection in C57BL/6 mice.The Journal of veterinary medical science · 2019Article
- Basal and Infectious Enteritis in Broilers Under the I See Inside Methodology: A Chronological Evaluation.Frontiers in veterinary science · 2019Article
- Anticoccidial activities of Chitosan on Eimeria papillata-infected mice.Parasitology research · 2016Article
- Course of induced infection by Eimeria krijgsmannni in immunocompetent and immunodeficient mice.Parasitology research · 2016Article
- Immunomodulatory and antiparasitic effects of garlic extract on Eimeria vermiformis-infected mice.Parasitology research · 2015Article
- Sex-determined susceptibility and differential MUC2 mRNA expression during the course of murine intestinal eimeriosis.Parasitology research · 2015Article
- Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum.International journal of nanomedicine · 2015Article
- Anti-coccidial, anthelmintic and antioxidant activities of pomegranate (Punica granatum) peel extract.Parasitology research · 2013Article
- Goblet cells and mucin related gene expression in mice infected with Eimeria papillata.TheScientificWorldJournal · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the gastrointestinal mucosa, mucus produced by goblet cells plays an important role in the defense against various pathogens. It is well known that some helminth parasites are able to up-regulate goblet cell numbers and alter the mucus components. However, the nature of the interactions between the protozoan parasites and goblet cells is still unclear. To clarify this point, we examined the goblet cell response in the small intestinal epithelium in C57BL/6 mice with Eimeria vermiformis infection. On day 6 post-infection (p.i.), we observed E. vermiformis multiplication followed by their destruction within the epithelium of the crypt. However, this was not observed in the villi. There was no evidence that the parasite destroyed the goblet cells; moreover, the number of goblet cells decreased in association with the development of the endogenous stages of E. vermiformis in the jejunum and ileum, but not in the duodenum. During this time, we observed infiltration into the lamina propria by lymphoid cells, such as plasma cells and lymphocytes with some eosinophils, in addition to villous atrophy. A significant reduction of goblet cell numbers occurred on days 8 and 10 p.i. Starting from day 12 p.i., elimination/termination of E. vermiformis was noted, and there was recovery of the villous epithelium along with regeneration of the crypt and goblet cells. The current study examined the reduction of goblet cells and their possible importance in eimerian infections.
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