ArticleEuropean journal of pediatrics2009
Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China.
Article in European journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Trial
- Predictive Factors and Clinical Markers of Recurrent Wheezing and Asthma After RSV Infection.Viruses · 2025Review
- Advances in cytokine gene polymorphisms in tuberculosis.mSphere · 2025Review
- Impact of genetic polymorphisms related to innate immune response on respiratory syncytial virus infection in children.Virus genes · 2022Review
- An overview on the RSV-mediated mechanisms in the onset of non-allergic asthma.Frontiers in pediatrics · 2022Review
- Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi-center prospective cohort study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Genotype-phenotype relationship of CCL5 in pulmonary tuberculosis infection inThe Indian journal of medical research · 2017Article
- Association of Chemotactic Chemokine Ligand 5 Polymorphisms with the Risk of Developing Severe Enterovirus 71 Infection.The American journal of tropical medicine and hygiene · 2015Article
- Respiratory syncytial virus--a comprehensive review.Clinical reviews in allergy & immunology · 2013Review
- CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection.Pediatric research · 2013Article
- Evidence for a causal relationship between respiratory syncytial virus infection and asthma.Expert review of anti-infective therapy · 2011Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the association among RANTES (regulated on activation normal T cell expressed and secreted) gene promoter polymorphism, serum RANTES levels, and recurrent wheezing after RSV (respiratory syncytial virus) bronchiolitis in children (1-12 months of age) from Han, Southern china. Three hundred twenty children with RSV bronchiolitis and 272 controls were enrolled in the 3-year follow-up study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP), enzyme-linked immunosorbent assay (ELISA) kit and luciferase analysis were the mainly used methods, which were used to genotype the RANTES (-403 G/A), assess the serum RANTES levels and the RANTES promoter activity. As the results showed, the RANTES (-403 G/A) in the promoter region was associated with recurrent wheezing after RSV bronchiolitis (p < 0.05) and serum RANTES levels (RANTES genotype G/G: 26.03 +/- 7.46 ng/ml G/A: 28.22 +/- 6.44 ng/ml A/A: 30.12 +/- 5.88 ng/ml). Functional analyses of RANTES promoter activity indicated that the RANTES (-403 G to A) mutation increases the transcriptional activity of the RANTES promoter. In conclusion, the RANTES (-403 G/A) polymorphism increases RANTES transcriptional activity resulted in a high serum RANTES levels, thus increased the risk of recurrent wheezing after RSV bronchiolitis.
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