ArticlePsychopharmacology2009
Environmental enrichment decreases the rewarding but not the activating effects of heroin.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice.Frontiers in veterinary science · 2022Pooled it
- Neighborhood perceptions are associated with tobacco dependence among African American smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Trial
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Neighborhood Vigilance in Terms of Abstinence Expectancies for Smoking and Severity of Problems When Quitting.Substance use & misuse · 2024Article
- Esketamine Inhibits Cocaine-Seeking Behaviour Subsequent to Various Abstinence Conditions in Rats.Biomolecules · 2023Article
- Claustral neurons projecting to frontal cortex restrict opioid consumption.Current biology : CB · 2023Article
- Article
- The systemic effects of the enriched environment on the conditioned fear reaction.Frontiers in behavioral neuroscience · 2023Review
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Valuing the Diversity of Research Methods to Advance Nutrition Science.Advances in nutrition (Bethesda, Md.) · 2022Article
- Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates.Journal of clinical medicine · 2022Article
- Environmental enrichment reduces heroin seeking following incubation of craving in both male and female rats.Drug and alcohol dependence · 2021Article
- Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse.Biomedicines · 2021Review
- Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens.Neuroscience and biobehavioral reviews · 2021Review
- Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Biomolecules · 2020Review
- Opposite regulation of conditioned place preference and intravenous drug self-administration in rodent models: Motivational and non-motivational examples.Neuroscience and biobehavioral reviews · 2020Review
- Environmental enrichment during forced abstinence from cocaine self-administration opposes gene network expression changes associated with the incubation effect.Scientific reports · 2020Article
- Endogenous Opioids at the Intersection of Opioid Addiction, Pain, and Depression: The Search for a Precision Medicine Approach.Annual review of neuroscience · 2020Review
- Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice.Psychopharmacology · 2020Article
- Therapeutic efficacy of environmental enrichment for substance use disorders.Pharmacology, biochemistry, and behavior · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleEnvironmental conditions during adolescence, a critical period of brain maturation, can have important consequences on subsequent vulnerability to drugs of abuse. We have recently found that the behavioral effects of cocaine as well as its ability to increase expression of zif-268 are reduced in mice reared in enriched environments (EE).
objectivesThe present experiments examined whether environmental enrichment has protective influences on the effects of heroin, a drug of addiction whose mechanism of action differs from that of cocaine. MATERIALS AND
methodsMice were housed either in standard environments (SE) or in EE from weaning to adulthood before any drug exposure. EE were constituted by big housing cages and contained constantly a running wheel and a small house and four to five toys that were changed once a week with new toys of different shapes and colors. We assessed the influence of EE on the ability of heroin to (1) induce conditioned place preferences, (2) induce behavioral sensitization, (3) increase dopamine levels in the nucleus accumbens (NAc), and (4) increase expression of the immediate early gene zif-268 in the striatum.
resultsConditioned place preference but not behavioral sensitization was reduced in EE mice compared to SE mice. Heroin induced similar increases in dopamine levels and in the expression of zif-268 in the NAc of EE and SE mice.
conclusionsThe rewarding effects of heroin are blunted by EE and appear to be, at least in part, independent from activation of the mesolimbic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.