ArticleOrganic & biomolecular chemistry2008
Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2',3'-cyclic phosphate RNA substrates.
Article in Organic & biomolecular chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cotranscriptional 3'-End Processing of T7 RNA Polymerase Transcripts by a Smaller HDV Ribozyme.Journal of molecular evolution · 2018Article
- A generalizable DNA-catalyzed approach to peptide-nucleic acid conjugation.Chembiochem : a European journal of chemical biology · 2014Article
- Catalytic DNA with phosphatase activity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Systematic evaluation of the dependence of deoxyribozyme catalysis on random region length.ACS combinatorial science · 2012Article
- Modular assembly of a Pd catalyst within a DNA scaffold for the amplified colorimetric and fluorimetric detection of nucleic acids.Angewandte Chemie (International ed. in English) · 2012Article
- Establishing broad generality of DNA catalysts for site-specific hydrolysis of single-stranded DNA.Nucleic acids research · 2012Article
- DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates.Biochemistry · 2011Article
- Functional compromises among pH tolerance, site specificity, and sequence tolerance for a DNA-hydrolyzing deoxyribozyme.Biochemistry · 2010Article
- Deoxyribozymes: selection design and serendipity in the development of DNA catalysts.Accounts of chemical research · 2009Review
- DNA-catalyzed sequence-specific hydrolysis of DNA.Nature chemical biology · 2009Article
- Use of deoxyribozymes in RNA research.Methods in enzymology · 2009Article
- Lanthanide ions as required cofactors for DNA catalysts.Chemical scienceArticle
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Authors and funding
4 authors.
Funding
Abstract
Our previous efforts have used in vitro selection to identify numerous Zn(2+)-dependent deoxyribozymes that ligate two RNA substrates with reaction at a 2',3'-cyclic phosphate. Each deoxyribozyme creates one of several different RNA linkages, including native 3'-5' and non-native 2'-5' phosphodiester bonds as well as many unnatural linkages. In this report, we describe experiments to reveal design aspects of the selection strategy that favor site-selective and regioselective synthesis of native 3'-5' RNA linkages. The results also reveal that an explicit selection pressure for RNA substrate sequence generality must be developed if the deoxyribozymes are to have practical generality.
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