ArticleTransplantation2008
Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets.
Article in Transplantation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Synthesis of siRNA-Conjugated Dextran-Coated Iron Oxide Nanoparticles for Islet Protection During Transplantation and Noninvasive Imaging.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Protection of Pancreatic Islets Using Theranostic Silencing Nanoparticles in a Baboon Model of Islet Transplantation.Diabetes · 2020Article
- Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus.Nano reviews & experiments · 2017Review
- Article
- Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model.International journal of cancer · 2013Article
- Theranostic magnetic resonance imaging of type 1 diabetes and pancreatic islet transplantation.Quantitative imaging in medicine and surgery · 2012Article
- Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy.Molecular pharmaceutics · 2012Article
- Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects.Advanced drug delivery reviews · 2011Review
- Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation.Diabetes · 2011Article
- Molecular imaging: a promising tool to monitor islet transplantation.Journal of transplantation · 2011Article
- Targeted imaging and therapy of brain cancer using theranostic nanoparticles.Molecular pharmaceutics · 2010Review
- Multimodality imaging probes: design and challenges.Chemical reviews · 2010Review
- Efficient gene delivery and silencing of mouse and human pancreatic islets.BMC biotechnology · 2010Article
- MRI as a tool to monitor islet transplantation.Nature reviews. Endocrinology · 2009Review
- In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates.Transplantation · 2009Article
- RNA interference for improving the outcome of islet transplantation.Advanced drug delivery reviewsReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundWith the ultimate hope of finding a cure for diabetes, researches are looking into altering the genetic profile of the beta cell as a way to manage metabolic dysregulation. One of the most powerful new approaches for the directed regulation of gene expression uses the phenomenon of RNA interference.
methodsHere, we establish the feasibility of a novel technology centered around multifunctional magnetic nanocarriers, which concurrently deliver siRNA to intact pancreatic islets and can be detected by magnetic resonance and optical imaging.
resultsIn the proof-of-principle studies described here, we demonstrate that, after in vitro incubation, magnetic nanoparticles carrying siRNA designed to target the model gene for enhanced green fluorescent protein are efficiently taken up by murine pancreatic islets, derived from egfp transgenic animals. This uptake can be visualized by magnetic resonance imaging and near-infrared fluorescence optical imaging and results in suppression of the target gene.
conclusionsThese results illustrate the value of our approach in overcoming the challenges associated with genetic modification of intact pancreatic islets in a clinically acceptable manner. Furthermore, an added advantage of our technology derives from the combined capability of our magnetic nanoparticles for siRNA delivery and magnetic labeling of pancreatic islets.
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