ArticleJournal of biosciences2008
Purification and molecular cloning of a new galactose-specific lectin from Bauhinia variegata seeds.
Article in Journal of biosciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 45 citations in OpenAlex.
- Novel Lectins fromACS omega · 2025Article
- Antifungal Effect of Bauhinia variegata Lectin (BvL) on Bipolaris oryzae.Current microbiology · 2024Article
- Cloning, Characterization, Expression Analysis, and Agglutination Studies of Novel Gene Encoding β-D-Galactose, N-Acetyl-D-Glucosamine and Lactose-Binding Lectin from Rice Bean (Vigna umbellata).Molecular biotechnology · 2022Article
- Research advances and prospects of legume lectins.Journal of biosciences · 2021Review
- From LC-MS/MS metabolomics profiling ofBioinformation · 2021Article
- Anti-inflammatory and antinociceptive activities ofBiochimie open · 2016Article
- Effect of leguminous lectins on the growth of Rhizobium tropici CIAT899.Molecules (Basel, Switzerland) · 2013Article
- Assessment of plant lectin antifungal potential against yeasts of major importance in medical mycology.Mycopathologia · 2013Article
- Structure predictions of two Bauhinia variegata lectins reveal patterns of C-terminal properties in single chain legume lectins.PloS one · 2013Article
- Effect of the lectin of Bauhinia variegata and its recombinant isoform on surgically induced skin wounds in a murine model.Molecules (Basel, Switzerland) · 2011Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new galactose-specific lectin was purified from seeds of a Caesalpinoideae plant, Bauhinia variegata, by affinity chromatography on lactose-agarose. Protein extracts haemagglutinated rabbit and human erythrocytes (native and treated with proteolytic enzymes), showing preference for rabbit blood treated with papain and trypsin. Among various carbohydrates tested, the lectin was best inhibited by D-galactose and its derivatives, especially lactose. SDS-PAGE showed that the lectin, named BVL, has a pattern similar to other lectins isolated from the same genus, Bauhinia purpurea agglutinin (BPA). The molecular mass of BVL subunit is 32 871 Da, determined by MALDI-TOF spectrometry. DNA extracted from B.variegata young leaves and primers designed according to the B. purpurea lectin were used to generate specific fragments which were cloned and sequenced, revealing two distinct isoforms. The bvl gene sequence comprised an open reading frame of 876 base pairs which encodes a protein of 291 amino acids. The protein carried a putative signal peptide. The mature protein was predicted to have 263 amino acid residues and 28 963 Da in size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.